TargetScore: TargetScore: Infer microRNA targets using microRNA-overexpression data and sequence information

Infer the posterior distributions of microRNA targets by probabilistically modelling the likelihood microRNA-overexpression fold-changes and sequence-based scores. Variaitonal Bayesian Gaussian mixture model (VB-GMM) is applied to log fold-changes and sequence scores to obtain the posteriors of latent variable being the miRNA targets. The final targetScore is computed as the sigmoid-transformed fold-change weighted by the averaged posteriors of target components over all of the features.

AuthorYue Li
Date of publicationNone
MaintainerYue Li <yueli@cs.toronto.edu>
LicenseGPL-2
Version1.12.0
http://www.cs.utoronto.ca/~yueli/software.html

View on Bioconductor

Files

TargetScore/DESCRIPTION
TargetScore/NAMESPACE
TargetScore/R
TargetScore/R/getTargetScores.R TargetScore/R/targetScore.R TargetScore/R/vbgmm.R
TargetScore/build
TargetScore/build/vignette.rds
TargetScore/inst
TargetScore/inst/CITATION
TargetScore/inst/NEWS
TargetScore/inst/doc
TargetScore/inst/doc/TargetScore.R
TargetScore/inst/doc/TargetScore.Rnw
TargetScore/inst/doc/TargetScore.pdf
TargetScore/inst/extdata
TargetScore/inst/extdata/realtestdata.RData
TargetScore/man
TargetScore/man/TargetScore-package.Rd TargetScore/man/bsxfun.se.Rd TargetScore/man/dot.ext.Rd TargetScore/man/getTargetScores.Rd TargetScore/man/initialization.Rd TargetScore/man/logmvgamma.Rd TargetScore/man/logsumexp.Rd TargetScore/man/sort_components.Rd TargetScore/man/targetScore.Rd TargetScore/man/vbgmm.Rd TargetScore/man/vbound.Rd TargetScore/man/vexp.Rd TargetScore/man/vmax.Rd
TargetScore/vignettes
TargetScore/vignettes/TargetScore.Rnw
TargetScore/vignettes/TargetScore.bib

Questions? Problems? Suggestions? or email at ian@mutexlabs.com.

Please suggest features or report bugs with the GitHub issue tracker.

All documentation is copyright its authors; we didn't write any of that.