Description Usage Format Details Source Examples
Precomputed data for use in the vignette, mostly for the sake of Windows, where gmapR and its tallying functionality are unsupported.
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The following objects are included:
Tallies for the two samples.
Coverage for the two samples.
A GRanges of the p53 exons
DNAStringSet with the genome sequence of the p53 region
The following demonstrates how we created these objects:
1 2 3 4 5 6 7 8 9 10 11 12 | bams <- LungCancerLines::LungCancerBamFiles()
tally.param <- TallyVariantsParam(gmapR::TP53Genome(),
high_base_quality = 23L,
which = range(p53) + 5e4,
indels = TRUE, read_length = 75L)
tallies_H1993 <- tallyVariants(bams$H1993, tally.param)
tallies_H2073 <- tallyVariants(bams$H2073, tally.param)
coverage_H1993 <- coverage(bams$H1993)
coverage_H2073 <- coverage(bams$H2073)
genome_p53 <- DNAStringSet(getSeq(gmapR::TP53Genome()))
p53 <- gmapR:::exonsOnTP53Genome("TP53")
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Computed from the data in the LungCancerLines package.
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