CLQD: partitioning into cliques

In gpart: Human genome partitioning of dense sequencing data by identifying haplotype blocks

Description

CLQD partitioning the given data into subgroups that contain SNPs which are highly correlated.

Usage

CLQD(geno, SNPinfo, CLQcut=0.5, clstgap=40000,
hrstType=c("near-nonhrst", "fast", "nonhrst"), hrstParam=200,
CLQmode=c("density", "maximal"), LD=c("r2", "Dprime"))

Arguments

geno	Data frame or matrix of additive genotype data, each column is additive genotype of each SNP. (Use data of non-monomorphic SNPs)
SNPinfo	Data frame or matrix of SNPs information. 1st column is rsID and 2nd column is bp position.
CLQcut	Numeric constant; a threshold for the LD measure value |r|, between 0 to 1. Default 0.5.
clstgap	Numeric constant; a threshold of physical distance (bp) between two consecutive SNPs which do not belong to the same clique, i.e., if a physical distance between two consecutive SNPs in a clique greater than clstgap, then the algorithm split the cliques satisfying each clique do not contain such consecutive SNPs. Default 40000.
hrstType	Character constant; heuristic methods. If you want to do not use heuristic algorithm, set hrstType = "nonhrst". If you want to use heuristic algorithm suggested in Kim et al.,(2017), set hrstType = "fast". That algorithm is fastest heuristic algorithm and suitable when your memory capacity is not greater than 8GB. If you want to obtain the results similar to the that of non-heuristic algorithm, set hrstType = "near-nonhrst".
hrstParam	Numeric constant; parameter for heuristic algorithm "near-nonhrst". Default is 200. It is recommended that you set the parameter to greater than 150.
CLQmode	Character constant; the way to give priority among detected cliques. if CLQmode = "density" then the algorithm gives priority to the clique of largest value of (Number of SNPs)/(range of clique), else if CLQmode = "maximal", then the algorithm gives priority to the largest clique. The default is "density".
LD	Character constant; LD measure to use, "r2" or "Dprime". Default "r2".

Value

A vector of cluster numbers of all SNPs (NA represents singleton cluster).

Author(s)

Sun-Ah Kim <[e-mail]>, Yun Joo Yoo <[e-mail]>

See Also

BigLD

Examples

data(geno)
data(SNPinfo)
CLQD(geno=geno[,1:100],SNPinfo=SNPinfo[1:100,])
## Not run: 
CLQD(geno=geno[,1:100],SNPinfo=SNPinfo[1:100,], CLQmode = 'maximal')
CLQD(geno=geno[,1:100],SNPinfo=SNPinfo[1:100,], LD='Dprime')

## End(Not run)

gpart documentation built on Nov. 8, 2020, 5:16 p.m.