methylSig: MethylSig: Differential Methylation Testing for WGBS and RRBS Data

MethylSig is a package for testing for differentially methylated cytosines (DMCs) or regions (DMRs) in whole-genome bisulfite sequencing (WGBS) or reduced representation bisulfite sequencing (RRBS) experiments. MethylSig uses a beta binomial model to test for significant differences between groups of samples. Several options exist for either site-specific or sliding window tests, and variance estimation.

Package details

AuthorYongseok Park [aut], Raymond G. Cavalcante [aut, cre]
Bioconductor views DNAMethylation DifferentialMethylation Epigenetics MethylSeq Regression
MaintainerRaymond G. Cavalcante <>
Package repositoryView on Bioconductor
Installation Install the latest version of this package by entering the following in R:
if (!requireNamespace("BiocManager", quietly = TRUE))


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methylSig documentation built on Nov. 8, 2020, 8:25 p.m.