sacurine: Analysis of the human adult urinary metabolome variations...

Description Format Value References

Description

Urine samples from 183 human adults were analyzed by liquid chromatography coupled to high-resolution mass spectrometry (LTQ Orbitrap) in the negative ionization mode. A total of 109 metabolites were identified or annotated at the MSI level 1 or 2. After retention time alignment with XCMS, peaks were integrated with Quan Browser. After signal drift and batch effect correction of intensities, each urine profile was normalized to the osmolality of the sample. Finally, the data were log10 transformed.

Format

A list with the following elements:

Value

List containing the 'dataMatrix' matrix (numeric) of data (samples as rows, variables as columns), the 'sampleMetadata' data frame of sample metadata, and the variableMetadata data frame of variable metadata. Row names of 'dataMatrix' and 'sampleMetadata' are identical. Column names of 'dataMatrix' are identical to row names of 'variableMetadata'. For details see the 'Format' section above.

References

Thevenot E.A., Roux A., Xu Y., Ezan E. and Junot C. (2015). Analysis of the human adult urinary metabolome variations with age, body mass index and gender by implementing a comprehensive workflow for univariate and OPLS statistical analyses. Journal of Proteome Research, DOI: 10.1021/acs.jproteome.5b00354


ropls documentation built on May 31, 2017, 11:03 a.m.