Significance Analysis of Function and Expression


SAFE is a resampling-based method for testing functional categories in gene expression experiments. SAFE can be applied to 2-sample and multi-class comparisons, or simple linear regressions. Other experimental designs can also be accommodated through user-defined functions.


Package: safe
Type: Package
Version: 3.0
Date: 2012-09-14
License: GPL (>= 2)
LazyLoad: yes

For an overview of how to use the package, including the most important functions, please see the included vignette.


William T. Barry

Maintainer: William T. Barry <>


W. T. Barry, A. B. Nobel and F.A. Wright, 2005, Significance Analysis of functional categories in gene expression studies: a structured permutation approach, Bioinformatics 21(9) 1943–1949.

See Also


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