tspair: Top Scoring Pairs for Microarray Classification

These functions calculate the pair of genes that show the maximum difference in ranking between two user specified groups. This "top scoring pair" maximizes the average of sensitivity and specificity over all rank based classifiers using a pair of genes in the data set. The advantage of classifying samples based on only the relative rank of a pair of genes is (a) the classifiers are much simpler and often more interpretable than more complicated classification schemes and (b) if arrays can be classified using only a pair of genes, PCR based tests could be used for classification of samples. See the references for the tspcalc() function for references regarding TSP classifiers.

Getting started

Package details

AuthorJeffrey T. Leek <jtleek@jhu.edu>
Bioconductor views Microarray
MaintainerJeffrey T. Leek <jtleek@jhu.edu>
Package repositoryView on Bioconductor
Installation Install the latest version of this package by entering the following in R:
if (!requireNamespace("BiocManager", quietly = TRUE))


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tspair documentation built on Nov. 8, 2020, 6:51 p.m.