TwoGrpCopriEndpt.SimPower: Power Simulation for Two Group Two Coprimary Endpoints Group...

In ADCT: Adaptive Design in Clinical Trials

Description

Given the group sequential design information, returns the simulated overall power.

Usage

TwoGrpCopriEndpt.SimPower(mu11,mu12, mu21, mu22, rho, tau,
 alpha1, alpha2, alternative , Nmax, B)

Arguments

mu11	standardized mean value for coprimary endpoint 1 in group 1.
mu12	standardized mean value for coprimary endpoint 2 in group 1.
mu21	standardized mean value for coprimary endpoint 1 in group 2.
mu22	standardized mean value for coprimary endpoint 2 in group 2.
rho	correlation coefficient between two coprimary endpoints.
tau	information time for the interim analysis.
alpha1	significant level for the first stage.
alpha2	significant level for the second stage.
alternative	indicates the alternative hypothesis and must be one of "two.sided" or "two.sided".
Nmax	maximum sample size per group.
B	the simulation iterative time.

Value

The evaluated power with attributes and computational error.

Author(s)

Yalin Zhu

References

Chang, M. (2014). Adaptive design theory and implementation using SAS and R. CRC Press.

Examples

# Example in Chang (2014) page  275
TwoGrpCopriEndpt.SimPower(mu11=0.2,mu12=0.25, mu21=0.005, mu22=0.015, rho=0.25,
tau=0.5, alpha1=0.0025, alpha2=0.024, alternative = "two.sided",Nmax=584, B=10000)

Example output

[1] 1e-04

ADCT documentation built on May 2, 2019, 9:40 a.m.