BOIN: Bayesian Optimal INterval (BOIN) Design for Single-Agent and Drug- Combination Phase I Clinical Trials

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The Bayesian optimal interval (BOIN) design is a novel phase I clinical trial design for finding the maximum tolerated dose (MTD). It can be used to design both single-agent and drug-combination trials. The BOIN design is motivated by the top priority and concern of clinicians when testing a new drug, which is to effectively treat patients and minimize the chance of exposing them to subtherapeutic or overly toxic doses. The prominent advantage of the BOIN design is that it achieves simplicity and superior performance at the same time. The BOIN design is algorithm-based and can be implemented in a simple way similar to the traditional 3+3 design. The BOIN design yields an average performance that is comparable to that of the continual reassessment method (CRM, one of the best model-based designs) in terms of selecting the MTD, but has a substantially lower risk of assigning patients to subtherapeutic or overly toxic doses.

Author
Ying Yuan and Suyu Liu
Date of publication
2016-08-09 01:37:10
Maintainer
Ying Yuan <yyuan@mdanderson.org>
License
GPL-2
Version
2.4

View on CRAN

Man pages

get.boundary
Generate the optimal dose escalation and deescalation...
get.oc
Generate operating characteristics for single agent trials
get.oc.comb
Generate operating characteristics for drug combination...
get.oc.comb.phase12
Get the operating characteristics for phase I/II waterfall...
next.comb
Determine the dose combination for the next cohort of new...
next.subtrial
Determine the starting dose and the dose-searching space for...
select.mtd
Select the maximum tolerated dose (MTD) for single agent...
select.mtd.comb
Select the maximum tolerated dose (MTD) or MTD contour for...

Files in this package

BOIN
BOIN/NAMESPACE
BOIN/R
BOIN/R/get.oc.comb.phase12.R
BOIN/R/select.mtd.comb.R
BOIN/R/get.oc.R
BOIN/R/select.mtd.R
BOIN/R/next.comb.R
BOIN/R/get.oc.comb.R
BOIN/R/get.boundary.R
BOIN/R/BOIN.R
BOIN/R/next.subtrial.R
BOIN/MD5
BOIN/DESCRIPTION
BOIN/man
BOIN/man/select.mtd.comb.Rd
BOIN/man/get.oc.comb.Rd
BOIN/man/get.oc.comb.phase12.Rd
BOIN/man/next.comb.Rd
BOIN/man/select.mtd.Rd
BOIN/man/next.subtrial.Rd
BOIN/man/get.boundary.Rd
BOIN/man/get.oc.Rd