print.boin: Generate descriptive summary for objects returned by other...

In BOIN: Bayesian Optimal INterval (BOIN) Design for Single-Agent and Drug- Combination Phase I Clinical Trials

Description

Generate descriptive summary for objects returned by other functions.

Usage

## S3 method for class 'boin'
print(x, ...)

Arguments

x	the object returned by other functions
...	ignored arguments

Details

print() prints the objects returned by other functions.

Value

print() prints the objects returned by other functions.

Author(s)

Suyu Liu, Liangcai Zhang, Yanhong Zhou, and Ying Yuan

Examples

###### single-agent trial ######

## sprint the object returned by get.boundary()
bound <- get.boundary(target=0.3, ncohort=10, cohortsize=3)
print(bound)


## print the object returned by get.oc()
oc.single <- get.oc(target=0.3, p.true=c(0.05, 0.15, 0.3, 0.45, 0.6), ncohort=10,
cohortsize=3, ntrial=1000)
print(oc.single)


## print the object returned by select.mtd()
n <- c(3, 3, 15, 9, 0)
y <- c(0, 0, 4, 4, 0)
selmtd <- select.mtd(target=0.3, npts=n, ntox=y)
print(selmtd)


###### drug-combination trial######

###### drug-combiation trial to find a single MTD ######

## print the object returned by next.comb()
n <- matrix(c(3, 0, 0, 0, 0, 0, 0, 0,  0, 0, 0, 0), ncol=4, byrow=TRUE)
y <- matrix(c(0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0), ncol=4, byrow=TRUE)
nxt.comb <- next.comb(target=0.25, npts=n, ntox=y, dose.curr=c(1, 1))
print(nxt.comb)


## print the object returned by next.comb()
n <- matrix(c(3, 3, 0, 0, 0, 0, 0, 0,  0, 0, 0, 0), ncol=4, byrow=TRUE)
y <- matrix(c(0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0), ncol=4, byrow=TRUE)
nxt.comb <- next.comb(target=0.25, npts=n, ntox=y, dose.curr=c(1, 2))
print(nxt.comb)


## print the object returned by get.oc.comb() when mtd.contour=FALSE
p.true <- matrix(c(0.02,0.04,0.08,0.14,
               0.08,0.25,0.42,0.48,
               0.25,0.45,0.50,0.60), byrow=TRUE, ncol=4)

oc.comb <- get.oc.comb(target=0.25, p.true=p.true, ncohort=16, cohortsize=3,
           ntrial=100)
print(oc.comb)


## print the object returned by select.mtd.comb()
n <- matrix(c(6, 3, 0, 0, 6, 24, 9, 0, 0, 0, 0, 0), ncol=4, byrow=TRUE)
y <- matrix(c(0, 0, 0, 0, 1, 5, 4, 0, 0, 0, 0, 0), ncol=4, byrow=TRUE)
sel.comb <- select.mtd.comb(target=0.25, npts=n, ntox=y)
print(sel.comb)



###### drug-combiation trial to find the MTD contour ######

## print the object returned by next.subtrial()
n <- matrix(c(6, 0,  0, 0,
           6, 0, 0, 0,
           9, 12, 0, 0), ncol=4, byrow=TRUE)
y <- matrix(c(0, 0, 0, 0,
           1, 0, 0, 0,
           2, 3, 0, 0), ncol=4, byrow=TRUE)
nxt.trial <- next.subtrial(target=0.3, npts=n, ntox=y)
print(nxt.trial)


## print the object returned by get.oc.comb() when mtd.contour=TRUE.
p.true <- matrix(c(0.01,0.03,0.10,0.20,0.30,
               0.03,0.05,0.15,0.30,0.60,
               0.08,0.10,0.30,0.60,0.75), byrow=TRUE, ncol=5)

oc.comb <- get.oc.comb(target=0.3, p.true, ncohort=c(10,5,5), cohortsize=3,
   n.earlystop=12, startdose=c(1,1),ntrial=100, mtd.contour=TRUE)
print(oc.comb)


## print the object returned by select.mtd.comb()
n <- matrix(c(6, 9, 24, 0,
           6,  24, 9, 0,
           12, 18, 0, 0), ncol=4, byrow=TRUE)
y <- matrix(c(0, 1, 5, 0,
           1, 5, 4, 0,
           1, 5, 0, 0), ncol=4, byrow=TRUE)
sel.comb2 <- select.mtd.comb(target=0.3, npts=n, ntox=y, mtd.contour=TRUE)
print(sel.comb2)

BOIN documentation built on Jan. 20, 2021, 1:06 a.m.