EWOC2-package: Escalation with Overdose Control using 2 Drug Combinations
In EWOC.Comb: Escalation with Overdose Control using 2 Drug Combinations
EWOC.Comb-package R Documentation
Escalation with Overdose Control using 2 Drug Combinations
Description
Implements Escalation With Overdose Control trial designs using two drug combinations described by this paper <doi:10.1002/sim.6961>(Tighiouart et al., 2016). It calculates the recommended dose for next cohorts and perform simulations to obtain operating characteristics.
Author(s)
Yujie Cui [aut, cre],
Quanlin Li [aut],
Mourad Tighiouart [aut]
Maintainer: Yujie Cui <yujie.cui@cshs.org>
References
Tighiouart M, Li Q and Rogatko A. A Bayesian adaptive design for estimating the maximuym tolerated dose curve using drug combinations in cancer phase I clinical trials. Statistics in Medicine. 2017, 36: 280-290.
EWOC.Comb documentation built on Sept. 11, 2024, 5:31 p.m.
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| EWOC.Comb-package | R Documentation |
Escalation with Overdose Control using 2 Drug Combinations
Description
Implements Escalation With Overdose Control trial designs using two drug combinations described by this paper <doi:10.1002/sim.6961>(Tighiouart et al., 2016). It calculates the recommended dose for next cohorts and perform simulations to obtain operating characteristics.
Author(s)
Yujie Cui [aut, cre], Quanlin Li [aut], Mourad Tighiouart [aut]
Maintainer: Yujie Cui <yujie.cui@cshs.org>
References
Tighiouart M, Li Q and Rogatko A. A Bayesian adaptive design for estimating the maximuym tolerated dose curve using drug combinations in cancer phase I clinical trials. Statistics in Medicine. 2017, 36: 280-290.
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