mtdcurve: Generating MTD curve based on logistic model for two drugs

In EWOC.Comb: Escalation with Overdose Control using 2 Drug Combinations

Generating MTD curve based on logistic model for two drugs

Description

Generating MTD curve based on logistic model for two drugs

Usage

mtdcurve(rho00, rho01, rho10, eta, theta)

Arguments

rho00	a numeric value indicating the true value of the parameter rho00, the probability of DLT when the levels of drugs A and B are both 0
rho01	a numeric value indicating the true value of the parameter rho01, the probability of DLT when the levels of drugs A and B are 0 and 1, respectively
rho10	a numeric value indicating the true value of the parameter rho10, the probability of DLT when the levels of drugs A and B are 1 and 0, respectively
eta	a numeric value indicating the true value of the eta, the interaction parameter
theta	a numerical value defining the proportion of expected patients to experience a medically unacceptable, dose-limiting toxicity (DLT) if administered the MTD

Value

a plot showing the MTD curve based on the logistic model

Examples

mtdcurve(rho00=0.01, rho01=0.2, rho10=0.9, eta=20, theta=0.2)

EWOC.Comb documentation built on Sept. 11, 2024, 5:31 p.m.