phenoRegressor.rrBLUP: SNP-BLUP or G-BLUP using rrBLUP package

In GROAN: Genomic Regression Workbench

SNP-BLUP or G-BLUP using rrBLUP package

Description

This is a wrapper around rrBLUP function mixed.solve. It can either work with genotypes (in form of a SNP matrix) or with kinships (in form of a covariance matrix). In the first case the function will implement a SNP-BLUP, in the second a G-BLUP. An error is returned if both SNPs and covariance matrix are passed.
In rrBLUP terms, genotypes are modeled as random effects (matrix Z), covariances as matrix K, and extra covariates, if present, as fixed effects (matrix X).
Please note that this function won't work if rrBLUP package is not installed.

Usage

phenoRegressor.rrBLUP(
  phenotypes,
  genotypes = NULL,
  covariances = NULL,
  extraCovariates = NULL,
  ...
)

Arguments

phenotypes	phenotypes, a numeric array (n x 1), missing values are predicted
genotypes	SNP genotypes, one row per phenotype (n), one column per marker (m), values in 0/1/2 for diploids or 0/1/2/...ploidy for polyploids. Can be NULL if covariances is present.
covariances	square matrix (n x n) of covariances.
extraCovariates	optional extra covariates set, one row per phenotype (n), one column per covariate (w). If NULL no extra covariates are considered.
...	extra parameters are passed to rrBLUP::mixed.solve

Value

The function returns a list with the following fields:

• predictions : an array of (k) predicted phenotypes

• hyperparams : named vector with the following keys: Vu, Ve, beta, LL

• extradata : list with information on trained model, coming from mixed.solve

See Also

mixed.solve

Other phenoRegressors: phenoRegressor.BGLR(), phenoRegressor.RFR(), phenoRegressor.SVR(), phenoRegressor.dummy(), phenoregressor.BGLR.multikinships()

Examples

## Not run: 
#using the GROAN.KI dataset, we regress on the dataset and predict the first ten phenotypes
phenos = GROAN.KI$yield
phenos[1:10]  = NA

#calling the regressor with ridge regression BLUP on SNPs and kinship
results.SNP.BLUP = phenoRegressor.rrBLUP(
  phenotypes = phenos,
  genotypes = GROAN.KI$SNPs,
  SE = TRUE, return.Hinv = TRUE #rrBLUP-specific parameters
)
results.G.BLUP = phenoRegressor.rrBLUP(
  phenotypes = phenos,
  covariances = GROAN.KI$kinship,
  SE = TRUE, return.Hinv = TRUE #rrBLUP-specific parameters
)

#examining the predictions
plot(GROAN.KI$yield, results.SNP.BLUP$predictions,
     main = '[SNP-BLUP] Train set (black) and test set (red) regressions',
     xlab = 'Original phenotypes', ylab = 'Predicted phenotypes')
abline(a=0, b=1)
points(GROAN.KI$yield[1:10], results.SNP.BLUP$predictions[1:10], pch=16, col='red')

plot(GROAN.KI$yield, results.G.BLUP$predictions,
     main = '[G-BLUP] Train set (black) and test set (red) regressions',
     xlab = 'Original phenotypes', ylab = 'Predicted phenotypes')
abline(a=0, b=1)
points(GROAN.KI$yield[1:10], results.G.BLUP$predictions[1:10], pch=16, col='red')

#printing correlations
correlations = data.frame(
  model = 'SNP-BLUP',
  test_set_correlations = cor(GROAN.KI$yield[1:10], results.SNP.BLUP$predictions[1:10]),
  train_set_correlations = cor(GROAN.KI$yield[-(1:10)], results.SNP.BLUP$predictions[-(1:10)])
)
correlations = rbind(correlations, data.frame(
  model = 'G-BLUP',
  test_set_correlations = cor(GROAN.KI$yield[1:10], results.G.BLUP$predictions[1:10]),
  train_set_correlations = cor(GROAN.KI$yield[-(1:10)], results.G.BLUP$predictions[-(1:10)])
))
print(correlations)

## End(Not run)

GROAN documentation built on Nov. 28, 2022, 5:07 p.m.