For continuous traits,
GWAF package provides two sets of functions for each of genome-wide association/interaction analyses
with observed/imputed SNP genotypes for family data. One fits Linear Mixed Effects (LME) model and the other fits Generalized Estimation Equation (GEE) model
to accounting for within pedigree correlation. While for dichotomous trait,
GWAF package provides functions to fit GEE model for
genome-wide association/interaction analyses. For rare variant analysis,
GWAF fits LME and generalized linear mixed effects (GLMM) model
for continuous traits and dichotomous traits, respectively. In addition,
also provides functions for making genome-wide p-values plot and QQ plot that contains genomic control
parameter estimate and generating scripts for genome-wide association analysis.
Please read UsingGWAF.pdf for more information including examples and description to output files.
|License:||GPL (>= 2)|
Qiong Yang <firstname.lastname@example.org> and Ming-Huei Chen <email@example.com>
Maintainer: Ming-Huei Chen <firstname.lastname@example.org>
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