The correlations and linkage disequilibrium between tests can vary as a function of minor allele frequency thresholds used to filter variants, and also varies with different choices of test statistic for region-based tests. Appropriate genome-wide significance thresholds can be estimated empirically through permutation on only a small proportion of the whole genome.
|Author||ChangJiang Xu and Celia M.T. Greenwood|
|Date of publication||2016-09-12 20:55:00|
|Maintainer||ChangJiang Xu <[email protected]>|
|License||GPL (>= 2)|
|Package repository||View on CRAN|
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