calc_internal_dose: Calculate internal chemical dose

In GeoTox: Spatiotemporal Mixture Risk Assessment

Calculate internal chemical dose

Description

Estimate the internal dose from inhalation of a chemical given inhalation rate, time, and body weight

Usage

calc_internal_dose(C_ext, IR, time = 1, BW = 1, scaling = 1)

Arguments

C_ext	ambient chemical concentration in \frac{mg}{m^3}
IR	inhalation rate in \frac{m^3}{day}
time	total time in days
BW	body weight in kg
scaling	scaling factor encompassing any required unit adjustments

Details

Input C_ext must be a matrix or list of matrices. Input IR must be an atomic vector or list of atomic vectors. The time, BW and scaling arguments are scalars.

The internal dose is calculated as:

D_{int} = \frac{C_{ext} \times IR \times time}{BW} \times scaling

Value

list of matrices containing internal chemical doses in \frac{mg}{kg}

Examples

# Single population
C_ext <- matrix(1:15, ncol = 3)
IR <- 1:5
calc_internal_dose(C_ext, IR)

# Multiple populations
C_ext <- list(
  "a" = matrix(1:15 / 10, ncol = 3),
  "b" = matrix(1:8, ncol = 2)
)
IR <- list(1:5, 1:4 / 2)
calc_internal_dose(C_ext, IR)

GeoTox documentation built on April 4, 2025, 5:07 a.m.