calc_invitro_concentration: Calculate _in vitro_ concentration

In GeoTox: Spatiotemporal Mixture Risk Assessment

Calculate in vitro concentration

Description

Estimate the in vitro equivalent plasma concentration given internal chemical dose and steady-state plasma concentration.

Usage

calc_invitro_concentration(D_int, C_ss = NULL)

Arguments

D_int	internal chemical dose in \frac{mg}{kg}
C_ss	steady-state plasma concentration in \frac{\mu M}{mg / kg}

Details

Input D_int must be a matrix or list of matrices. Input C_ss must be a numeric atomic vector or matrix, or a list of those types.

The in vitro equivalent plasma concentration is calculated as:

C_{plasma} = C_{ss} \times D_{int}

Value

list of matrices containing concentrations in \mu M

Examples

# Single population
D_int <- matrix(1:15, ncol = 3)
C_ss <- 1:5
calc_invitro_concentration(D_int, C_ss)

# Multiple populations
D_int <- list(
  "a" = matrix(1:15 / 10, ncol = 3),
  "b" = matrix(1:8, ncol = 2)
)
C_ss <- list(1:5, 1:4 / 2)
calc_invitro_concentration(D_int, C_ss)

GeoTox documentation built on April 4, 2025, 5:07 a.m.