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HiCblock: Systematic Analysis of Architectural Proteins and Functional Elements in Blocking Long-Range Contacts Between Loci
Here we propose a model to systematically analyze the roles of architectural proteins and functional elements in blocking long-range contacts between loci. The proposed model does not rely on topologically associating domain (TAD) mapping from Hi-C data. Instead of testing the enrichment or influence of protein binding at TAD borders, the model directly estimates the blocking effect of proteins on long-range contacts between flanking loci, making the model intuitive and biologically meaningful.
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Package details |
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| Author | Raphael Mourad |
| Maintainer | Raphael Mourad <raphael.mourad@ibcg.biotoul.fr> |
| License | GPL-2 |
| Version | 1.5 |
| Package repository | View on CRAN |
| Installation |
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