penetrance: Likelihood function for calculation of Pedigree-based...

In KinformR: Relationship-Informed Pedigree and Variant Scoring

Likelihood function for calculation of Pedigree-based autosomal dominant penetrance value. Formula deployed via optimize so as to determine the optimal value.

Description

Likelihood function for calculation of Pedigree-based autosomal dominant penetrance value. Formula deployed via optimize so as to determine the optimal value.

Usage

penetrance(K, a, b, c, d, n)

Arguments

K	The range of penetrance values to be explored by the optimization function.
a	Count of affected individuals
b	Count of obligate carriers
c	Count of children of either affecteds or carriers, with no children of their own
d	Count of trees of unaffected individuals - specifically, two sequential generations (i.e. a parent and their offspring)
n	Count of the number of second generation progeny in a given tree.

Value

K Pedigree-based estimation of autosomal dominant penetrance rate.

Examples

K <- optimize(penetrance, c(0,1), 3, 1, 5, 2, 1, maximum=TRUE)$max

KinformR documentation built on Feb. 17, 2026, 5:07 p.m.