The Function for Likelihood Ratio Test Accounting for Genetic Heterogeneity
It gives the asymptotic p-value of the LRT_H test.
a n x 1 vector of genotypic score for SNP (i.e. 0, 1 or 2, the number of minor alleles of a SNP); n is the number of observations.
a n x 1 vector of disease status; case/xcontrol: 1/0; ; n is the number of observations.
Missing values in either x or y (i.e. genotype or disease status) will be removed.
The asymptotic p-value of LRT_H test.
Zhiyuan (Jason) Xu and Wei Pan
Qian M., Shao Y., 2013. A Likelihood Ratio Test for Genome-Wide Association under Genetic Heterogeneity. Annals of Human Genetics, 77(2): 174-182.
Zhou H., Pan W., 2009. Binomial Mixture Model-based Association Tests under Genetic Heterogeneity. Annals of Human Genetics, 73(6): 614-630.
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