Mixed effects Score Test

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Description

Test for association between a set of SNPS/genes and continuous or binary outcomes by including variant characteristic information and using score statistics.

Details

Package: MiST
Type: Package
Version: 1.0
Date: 2013-03-18
License: LGPL (>= 2.0)
LazyLoad: yes

linear.test(y, X, G, Z, method = "liu")

linear.weight.test(y, X, G, Z, maf, weight.beta = c(1, 25), method = "liu")

logit.test(y, X, G, Z, method = "liu")

logit.weight.test(y, X, G, Z, maf, weight.beta = c(1, 25), method = "liu")

Author(s)

Jianping Sun, Yingye Zheng, and Li Hsu.

References

Sun, J., Zheng, Y., and Hsu, L. (2013) A Unified Mixed-Effects Model for Rare-Variant Association in Sequencing Studies. Genet Epidemiol. 2013 Mar 9. doi: 10.1002/gepi.21717

H. Liu, Y. Tang, H.H. Zhang (2009) A new chi-square approximation to the distribution of non-negative definite quadratic forms in non-central normal variables, Computational Statistics and Data Analysis, 53, 853-856.