Nothing

```
SubstDesign <- function(PX2 = NULL,PX1 = NULL){
if(is.null(PX1) | is.null(PX2) ){stop("The user must enter two design sets")}
d <- dim(as.matrix(PX2))[2]
n2 <- dim(as.matrix(PX2))[1]
n1 <- dim(as.matrix(PX1))[1]
dist <- 0
for(i in 1:d){
grid <- expand.grid(PX2[,i],PX1[,i])
dist <- dist + (grid[,1]-grid[,2])^2
}
Matdist <- matrix(dist,n2,n1)
indice <- max.col(-(Matdist))
PX1 <- as.matrix(PX1[-indice,])
PX1 <- rbind(PX1,PX2)
return(list(PX = PX1,le = length(indice)))
}
```

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