LCC_Significance: LCC_Significance

In NetSci: Calculates Basic Network Measures Commonly Used in Network Medicine

Description

Calculates the Largest Connected Component (LCC) from a given graph, and calculates its significance using a degree preserving approach. Menche, J., et al (2015) <doi.org:10.1126/science.1065103>

Usage

LCC_Significance(
  N = N,
  Targets = Targets,
  G,
  bins = 100,
  hypothesis = "greater",
  min_per_bin = 20
)

Arguments

N	Number of randomizations.
Targets	Name of the nodes that the subgraph will focus on - Those are the nodes you want to know whether if forms an LCC.
G	The graph of interest (often, in NetMed it is an interactome - PPI).
bins	the number os bins for the degree preserving randomization.
hypothesis	are you expecting an LCC greater or smaller than the average?
min_per_bin	the minimum size of each bin.

Value

a list with the LCC - $LCCZ all values from the randomizations - $mean the average LCC of the randomizations - $sd the sd LCC of the randomizations - $Z The score - $LCC the LCC of the given targets - $emp\_p the empirical p-value for the LCC

Examples

set.seed(666)
net  = data.frame(
Node.1 = sample(LETTERS[1:15], 15, replace = TRUE),
Node.2 = sample(LETTERS[1:10], 15, replace = TRUE))
net$value = 1
net =  CoDiNA::OrderNames(net)
net = unique(net)

g <- igraph::graph_from_data_frame(net, directed = FALSE )
plot(g)
targets = c("I", "H", "F", "E")
LCC_Significance(N = 100,
                 Targets = targets,
                                  G = g,
                                  bins = 5,
                                  min_per_bin = 2)
                                  # in a real interactome, please use the default

NetSci documentation built on Dec. 11, 2021, 9:21 a.m.