Man pages for PFIM
Population Fisher Information Matrix
| addModel | Add a model to a library of models. |
| addModels | Add a models to a library of models. |
| Administration-class | Class "Administration" |
| AdministrationConstraints-class | Class "AdministrationConstraints" |
| Arm-class | Class "Arm" |
| BayesianFim-class | Class "BayesianFim" |
| checkSamplingTimeConstraintsForContinuousOptimization | Check for the samplingTime constraints for continuous... |
| checkValiditySamplingConstraint | checkValiditySamplingConstraint |
| Combined1-class | Class "Combined1" |
| Constant-class | Class "Constant" |
| convertPKModelAnalyticToPKModelODE | Convert an analytic model to a ode model. |
| defineModel | Define a model. |
| defineModelFromLibraryOfModels | Define a model from the library of models. |
| defineModelType | Define the type of a model. |
| defineModelUserDefined | Define a user defined model. |
| definePKModel | Define a PK model. |
| definePKPDModel | Define a PKPD model. |
| Design-class | Class "Design" |
| Distribution-class | Class "Distribution" |
| EvaluateArm | EvaluateArm |
| EvaluateDesign | EvaluateDesign |
| EvaluateErrorModelDerivatives | Evaluate the error model derivatives. |
| EvaluateFisherMatrix | Evaluate the Fisher matrix ( population, individual and... |
| EvaluateModel | Evaluate a model. |
| EvaluateVarianceFIM | Evaluate the variance of the Fisher information matrix. |
| EvaluateVarianceModel | Evaluate the variance of a model. |
| Evaluation-class | Class "Evaluation" |
| FedorovWynnAlgorithm-class | Class "FedorovWynnAlgorithm" |
| FedorovWynnAlgorithm_Rcpp | Fedorov-Wynn algorithm in Rcpp. |
| Fim-class | Class "Fim" |
| fisher.simplex | Compute the fisher.simplex |
| fun.amoeba | function fun.amoeba |
| generateFimsFromConstraints | Generate the fim from the constraints |
| generateReportEvaluation | Generate the report for the evaluation |
| generateReportOptimization | Generate report for the optimization. |
| generateSamplingsFromSamplingConstraints | Generate samplings from sampling constraints |
| generateTables | Generate the tables for the report. |
| getAdjustedGradient | getAdjustedGradient |
| getAdministration | getAdministration |
| getAdministrationConstraint | getAdministrationConstraint |
| getAdministrations | getAdministrations |
| getAdministrationsConstraints | getAdministrationsConstraints |
| getArms | Get the arms of an object. |
| getcError | Get the parameter c. |
| getColumnAndParametersNamesFIM | Get the names of the names of the parameters associated to... |
| getColumnAndParametersNamesFIMInLatex | Get the names of the names of the parameters associated to... |
| getConditionNumberFixedEffects | Get the condition number of the matrix of the fixed effects. |
| getConditionNumberVarianceEffects | Get the condition number of the matrix of the variance... |
| getContent | Get content of a library of models. |
| getCorrelationMatrix | Get the correlation matrix. |
| getDataFrameResults | Get the dataframe of the results. |
| getDcriterion | Get the D criterion of the fim. |
| getDelta | Get the parameter delta |
| getDerivatives | Get the derivatives of the model error equation. |
| getDescription | Get the description of a model. |
| getDesigns | Get the designs. |
| getDeterminant | Get the determinant of the fim. |
| getDistribution | Get the distribution. |
| getDose | getDose |
| getEigenValues | Get the eigenvalues of the fim. |
| getElementaryProtocols | Get the elementary protocols. |
| getEquation | Get the equation of a model error. |
| getEquations | Get the equations of a model. |
| getEquationsAfterInfusion | Get the equations after infusion. |
| getEquationsDuringInfusion | Get the equations during infusion. |
| getEvaluationFIMResults | Get the results of the evaluation. |
| getEvaluationInitialDesignResults | Get the evaluation results of the initial design. |
| getFim | getFim |
| getFisherMatrix | Get the FIM. |
| getFixedEffects | Get the matrix of fixed effects. |
| getFixedMu | Get the fixed effect. |
| getFixedOmega | Get the fixed variance. |
| getFixedParameters | Get the fixed parameters. |
| getFixedTimes | Get the fixed sampling times. |
| getInitialConditions | getInitialConditions |
| getIterationAndCriteria | Get the iteration with the convergence criteria. |
| getLambda | Get the parameter lambda. |
| getLibraryPDModels | Get the library of PD models. |
| getLibraryPKModels | Get the library of PK models. |
| getMinSampling | Get the minimal sampling times. |
| getModel | Get the model. |
| getModelEquations | Get the model equations. |
| getModelError | Get the model error. |
| getModelErrorParametersValues | Get the values of the model error parameters. |
| getModelFromLibrary | Get a model from the library of models. |
| getModelParameters | Get the model parameters. |
| getModelParametersValues | Get the values of the model parameters. |
| getMu | getMu |
| getName | getName |
| getNames | getNames |
| getNumberOfArms | getNumberOfArms |
| getNumberOfIterations | Get the number of iterations. |
| getNumberOfParameters | Get the number of parameters. |
| getNumberOfsamplingsOptimisable | Get the number of sampling times that are optimisable. |
| getNumberOfTimesByWindows | Get the number of sampling times by windows. |
| getOdeSolverParameters | getOdeSolverParameters |
| getOmega | Get the matrix omega of an object. |
| getOptimalDesign | Get the optimal design. |
| getOptimalWeights | Get the optimal weights. |
| getOptimizationResults | Get the optimization results. |
| getOptimizer | Get the optimization algorithm. |
| getOptimizerParameters | Get the optimization parameters. |
| getOutcome | getOutcome |
| getOutcomes | Get the outcomes of a model. |
| getOutcomesEvaluation | getOutcomesEvaluation |
| getOutcomesForEvaluation | Get the outcomes of a model used for the evaluation (is... |
| getOutcomesGradient | getOutcomesGradient |
| getParameters | Get the parameters of an object. |
| getPDModel | Get a PD model. |
| getPKModel | Get a PK model. |
| getPKPDModel | Get a PKPD model. |
| getPlotOptions | Get the plot options for graphs responses and SI |
| getProportionsOfSubjects | Get the proportion of subjects. |
| getRSE | Get the RSE |
| getSamplings | Get the sampling of an object. |
| getSamplingsWindows | Get the windows for the sampling times. |
| getSamplingTime | getSamplingTime |
| getSamplingTimeConstraint | getSamplingTimeConstraint |
| getSamplingTimes | getSamplingTimes |
| getSamplingTimesConstraints | getSamplingTimesConstraints |
| getSE | Get the SE. |
| getShrinkage | Get the shrinkage. |
| getSigmaInter | Get the parameter sigma inter. |
| getSigmaSlope | Get the parameter sigma slope. |
| getSize | getSize |
| getTau | getTau |
| getTimeDose | getTimeDose |
| getTinf | Get the infusion duration. |
| getVarianceEffects | Get the matrix of the variance effects. |
| IndividualFim-class | Class "Fim" |
| isDoseInEquations | Test if the dose is in the equations of the model. |
| isModelAnalytic | Test if a mode is analytic. |
| isModelBolus | Test if a mode is bolus. |
| isModelInfusion | Test if a mode is infusion |
| isModelODE | Test if a mode is ode. |
| isModelSteadyState | Test if a mode is steady state. |
| LibraryOfModels-class | Class "LibraryOfModels" |
| LibraryOfPDModels | Library of the PK models |
| LibraryOfPKModels | Library of the PK models |
| LibraryOfPKPDModels-class | Class "LibraryOfPKPDModels" |
| LogNormal-class | Class "LogNormal" |
| ModelAnalyticBolus-class | Class "ModelAnalyticBolus" |
| ModelAnalyticBolusSteadyState-class | Class "ModelAnalyticBolusSteadyState" |
| ModelAnalytic-class | Class "ModelAnalytic" |
| ModelAnalyticInfusion-class | Class "ModelAnalyticInfusion" |
| ModelAnalyticInfusionSteadyState-class | Class "ModelAnalyticInfusionSteadyState" |
| ModelAnalyticSteadyState-class | Class "ModelAnalyticSteadyState" |
| ModelBolus-class | Class "ModelBolus" |
| Model-class | Class "Model" |
| ModelError-class | Class "ModelError" representing a Model error. |
| ModelInfusion-class | Class "ModelInfusion" |
| ModelODEBolus-class | Class "ModelODEBolus" |
| ModelODE-class | Class "ModelODE" |
| ModelODEDoseInEquations-class | Class "ModelODEDoseInEquations" |
| ModelODEDoseNotInEquations-class | Class "ModelODEDoseNotInEquations" |
| ModelODEInfusion-class | Class "ModelODEInfusion" |
| ModelODEInfusionDoseInEquations-class | Class "ModelODEInfusionDoseInEquations" |
| ModelParameter-class | Class "ModelParameter" |
| MultiplicativeAlgorithm-class | Class "MultiplicativeAlgorithm" |
| MultiplicativeAlgorithm_Rcpp | Function MultiplicativeAlgorithm_Rcpp |
| Normal-class | Class "Normal" |
| OptimizationAlgorithm-class | Class "OptimizationAlgorithm" |
| Optimization-class | Class "Optimization" |
| optimize | Optimize a design. |
| parametersForComputingGradient | Define the parameters for computing the gradients of a model. |
| PFIM-package | Fisher Information matrix for design evaluation/optimization... |
| PFIMProject-class | Class "PFIMProject" |
| PGBOAlgorithm-class | Class "PGBOAlgorithm" |
| plot | Graphs of the results of the evaluation. |
| PlotEvaluation-class | Class "PlotEvaluation" |
| plotOutcomesEvaluation | plotOutcomesEvaluation |
| plotOutcomesGradient | plotOutcomesGradient |
| plotRSE | Graph of the RSE. |
| plotSE | Graph the SE. |
| plotShrinkage | Graph of the shrinkage. |
| plotWeights | Graph of the weights for the multiplicative algorithm. |
| PopulationFim-class | Class "PopulationFim" |
| Proportional-class | Class "Proportional" |
| PSOAlgorithm-class | Class "PSOAlgorithm" |
| Report | Report |
| reportTablesAdministration | reportTablesAdministration |
| reportTablesDesign | reportTablesDesign |
| reportTablesFIM | Generate the tables for the report. |
| reportTablesModelError | Generate the tables for model errors for the evaluation... |
| reportTablesModelParameters | Generate the tables for model parameters for the evaluation... |
| reportTablesPlot | reportTablesPlot |
| reportTablesSamplingConstraints | reportTablesSamplingConstraints |
| resizeFisherMatrix | Resize the fisher Matrix from a vector to a matrix. |
| run | run |
| SamplingTimeConstraints-class | Class "SamplingTimeConstraints" |
| SamplingTimes-class | Class "SamplingTimes" |
| setAdministrations | setAdministrations |
| setArm | setArm |
| setArms | Set the arms of an object. |
| setcError | Set the parameter c. |
| setContent | Set content of a library of models. |
| setDerivatives | Set the derivatives of the model error equation. |
| setDescription | Set the description of a model. |
| setDesigns | Set the designs. |
| setDistribution | Set the distribution. |
| setDose | Set the amount of dose |
| setEquation | Set the equation of a model error. |
| setEquations | Set the equations of a model. |
| setEquationsAfterInfusion | Set the equations after infusion. |
| setEquationsDuringInfusion | Set the equations during infusion. |
| setEvaluationFIMResults | Set the evaluation results. |
| setEvaluationInitialDesignResults | Set the evaluation results of the initial design. |
| setFim | setFim |
| setFimTypeToString | Convert the type of the object fim to a string. |
| setFisherMatrix | Set the FIM. |
| setFixedEffects | Set the fixed effects. |
| setFixedMu | Set the mu as fixed or not. |
| setFixedOmega | Set the omega as fixed of not. |
| setInitialConditions | setInitialConditions |
| setIterationAndCriteria | Set the iteration with the convergence criteria. |
| setModel | Set the model. |
| setModelError | Set the model error. |
| setModelFromLibrary | Set a model from the library of model |
| setMu | Set the value of the fixed effect mu of an object. |
| setName | Set the name of an object. |
| setNumberOfArms | setNumberOfArms |
| setOdeSolverParameters | Set the parameters of the ode solver. |
| setOmega | Set the matrix omega of an object. |
| setOptimalDesign | Set the optimal design. |
| setOptimalWeights | Set the optimal weights. |
| setOptimizationResults | Set the optimization results. |
| setOutcome | setOutcome |
| setOutcomes | Set the outcomes of a model. |
| setOutcomesEvaluation | setOutcomesEvaluation |
| setOutcomesForEvaluation | Set the outcomes of a model used for the evaluation (is... |
| setOutcomesGradient | setOutcomesGradient |
| setParameters | Set the parameters of an object. |
| setSamplingConstraintForOptimization | setSamplingConstraintForOptimization |
| setSamplings | Set the sampling times. |
| setSamplingTime | setSamplingTime |
| setSamplingTimes | setSamplingTimes |
| setSamplingTimesConstraints | setSamplingTimesConstraints |
| setShrinkage | Set the shrinkage. |
| setSigmaInter | Set the parameter sigma inter. |
| setSigmaSlope | Set the parameter sigma slope. |
| setSize | setSize |
| setTau | setTau |
| setTimeDose | setTimeDose |
| setTinf | Set the infusion duration. |
| setVarianceEffects | Set the matrix of the variance effects. |
| show | show |
| SimplexAlgorithm-class | Class "SimplexAlgorithm" |
