Population Fisher Information Matrix

addModel | Add a model to a library of models. |

addModels | Add a models to a library of models. |

Administration-class | Class "Administration" |

AdministrationConstraints-class | Class "AdministrationConstraints" |

Arm-class | Class "Arm" |

BayesianFim-class | Class "BayesianFim" |

checkSamplingTimeConstraintsForContinuousOptimization | Check for the samplingTime constraints for continuous... |

checkValiditySamplingConstraint | checkValiditySamplingConstraint |

Combined1-class | Class "Combined1" |

Constant-class | Class "Constant" |

convertPKModelAnalyticToPKModelODE | Convert an analytic model to a ode model. |

defineModel | Define a model. |

defineModelFromLibraryOfModels | Define a model from the library of models. |

defineModelType | Define the type of a model. |

defineModelUserDefined | Define a user defined model. |

definePKModel | Define a PK model. |

definePKPDModel | Define a PKPD model. |

Design-class | Class "Design" |

Distribution-class | Class "Distribution" |

EvaluateArm | EvaluateArm |

EvaluateDesign | EvaluateDesign |

EvaluateErrorModelDerivatives | Evaluate the error model derivatives. |

EvaluateFisherMatrix | Evaluate the Fisher matrix ( population, individual and... |

EvaluateModel | Evaluate a model. |

EvaluateVarianceFIM | Evaluate the variance of the Fisher information matrix. |

EvaluateVarianceModel | Evaluate the variance of a model. |

Evaluation-class | Class "Evaluation" |

FedorovWynnAlgorithm-class | Class "FedorovWynnAlgorithm" |

FedorovWynnAlgorithm_Rcpp | Fedorov-Wynn algorithm in Rcpp. |

Fim-class | Class "Fim" |

fisher.simplex | Compute the fisher.simplex |

fun.amoeba | function fun.amoeba |

generateFimsFromConstraints | Generate the fim from the constraints |

generateReportEvaluation | Generate the report for the evaluation |

generateReportOptimization | Generate report for the optimization. |

generateSamplingsFromSamplingConstraints | Generate samplings from sampling constraints |

generateTables | Generate the tables for the report. |

getAdjustedGradient | getAdjustedGradient |

getAdministration | getAdministration |

getAdministrationConstraint | getAdministrationConstraint |

getAdministrations | getAdministrations |

getAdministrationsConstraints | getAdministrationsConstraints |

getArms | Get the arms of an object. |

getcError | Get the parameter c. |

getColumnAndParametersNamesFIM | Get the names of the names of the parameters associated to... |

getColumnAndParametersNamesFIMInLatex | Get the names of the names of the parameters associated to... |

getConditionNumberFixedEffects | Get the condition number of the matrix of the fixed effects. |

getConditionNumberVarianceEffects | Get the condition number of the matrix of the variance... |

getContent | Get content of a library of models. |

getCorrelationMatrix | Get the correlation matrix. |

getDataFrameResults | Get the dataframe of the results. |

getDcriterion | Get the D criterion of the fim. |

getDelta | Get the parameter delta |

getDerivatives | Get the derivatives of the model error equation. |

getDescription | Get the description of a model. |

getDesigns | Get the designs. |

getDeterminant | Get the determinant of the fim. |

getDistribution | Get the distribution. |

getDose | getDose |

getEigenValues | Get the eigenvalues of the fim. |

getElementaryProtocols | Get the elementary protocols. |

getEquation | Get the equation of a model error. |

getEquations | Get the equations of a model. |

getEquationsAfterInfusion | Get the equations after infusion. |

getEquationsDuringInfusion | Get the equations during infusion. |

getEvaluationFIMResults | Get the results of the evaluation. |

getEvaluationInitialDesignResults | Get the evaluation results of the initial design. |

getFim | getFim |

getFisherMatrix | Get the FIM. |

getFixedEffects | Get the matrix of fixed effects. |

getFixedMu | Get the fixed effect. |

getFixedOmega | Get the fixed variance. |

getFixedParameters | Get the fixed parameters. |

getFixedTimes | Get the fixed sampling times. |

getInitialConditions | getInitialConditions |

getIterationAndCriteria | Get the iteration with the convergence criteria. |

getLambda | Get the parameter lambda. |

getLibraryPDModels | Get the library of PD models. |

getLibraryPKModels | Get the library of PK models. |

getMinSampling | Get the minimal sampling times. |

getModel | Get the model. |

getModelEquations | Get the model equations. |

getModelError | Get the model error. |

getModelErrorParametersValues | Get the values of the model error parameters. |

getModelFromLibrary | Get a model from the library of models. |

getModelParameters | Get the model parameters. |

getModelParametersValues | Get the values of the model parameters. |

getMu | getMu |

getName | getName |

getNames | getNames |

getNumberOfArms | getNumberOfArms |

getNumberOfIterations | Get the number of iterations. |

getNumberOfParameters | Get the number of parameters. |

getNumberOfsamplingsOptimisable | Get the number of sampling times that are optimisable. |

getNumberOfTimesByWindows | Get the number of sampling times by windows. |

getOdeSolverParameters | getOdeSolverParameters |

getOmega | Get the matrix omega of an object. |

getOptimalDesign | Get the optimal design. |

getOptimalFrequencies | Get the optimal frequencies |

getOptimalWeights | Get the optimal weights. |

getOptimizationResults | Get the optimization results. |

getOptimizer | Get the optimization algorithm. |

getOptimizerParameters | Get the optimization parameters. |

getOutcome | getOutcome |

getOutcomes | Get the outcomes of a model. |

getOutcomesEvaluation | getOutcomesEvaluation |

getOutcomesForEvaluation | Get the outcomes of a model used for the evaluation (is... |

getOutcomesGradient | getOutcomesGradient |

getParameters | Get the parameters of an object. |

getPDModel | Get a PD model. |

getPKModel | Get a PK model. |

getPKPDModel | Get a PKPD model. |

getPlotOptions | Get the plot options for graphs responses and SI |

getProportionsOfSubjects | Get the proportion of subjects. |

getRSE | Get the RSE |

getSamplings | Get the sampling of an object. |

getSamplingsWindows | Get the windows for the sampling times. |

getSamplingTime | getSamplingTime |

getSamplingTimeConstraint | getSamplingTimeConstraint |

getSamplingTimes | getSamplingTimes |

getSamplingTimesConstraints | getSamplingTimesConstraints |

getSE | Get the SE. |

getShrinkage | Get the shrinkage. |

getSigmaInter | Get the parameter sigma inter. |

getSigmaSlope | Get the parameter sigma slope. |

getSize | getSize |

getTau | getTau |

getTimeDose | getTimeDose |

getTinf | Get the infusion duration. |

getVarianceEffects | Get the matrix of the variance effects. |

IndividualFim-class | Class "Fim" |

isDoseInEquations | Test if the dose is in the equations of the model. |

isModelAnalytic | Test if a mode is analytic. |

isModelBolus | Test if a mode is bolus. |

isModelInfusion | Test if a mode is infusion |

isModelODE | Test if a mode is ode. |

isModelSteadyState | Test if a mode is steady state. |

LibraryOfModels-class | Class "LibraryOfModels" |

LibraryOfPDModels | Library of the PK models |

LibraryOfPKModels | Library of the PK models |

LibraryOfPKPDModels-class | Class "LibraryOfPKPDModels" |

LogNormal-class | Class "LogNormal" |

ModelAnalyticBolus-class | Class "ModelAnalyticBolus" |

ModelAnalyticBolusSteadyState-class | Class "ModelAnalyticBolusSteadyState" |

ModelAnalytic-class | Class "ModelAnalytic" |

ModelAnalyticInfusion-class | Class "ModelAnalyticInfusion" |

ModelAnalyticInfusionSteadyState-class | Class "ModelAnalyticInfusionSteadyState" |

ModelAnalyticSteadyState-class | Class "ModelAnalyticSteadyState" |

ModelBolus-class | Class "ModelBolus" |

Model-class | Class "Model" |

ModelError-class | Class "ModelError" representing a Model error. |

ModelInfusion-class | Class "ModelInfusion" |

ModelODEBolus-class | Class "ModelODEBolus" |

ModelODE-class | Class "ModelODE" |

ModelODEDoseInEquations-class | Class "ModelODEDoseInEquations" |

ModelODEDoseNotInEquations-class | Class "ModelODEDoseNotInEquations" |

ModelODEInfusion-class | Class "ModelODEInfusion" |

ModelODEInfusionDoseInEquations-class | Class "ModelODEInfusionDoseInEquations" |

ModelParameter-class | Class "ModelParameter" |

MultiplicativeAlgorithm-class | Class "MultiplicativeAlgorithm" |

MultiplicativeAlgorithm_Rcpp | Function MultiplicativeAlgorithm_Rcpp |

Normal-class | Class "Normal" |

OptimizationAlgorithm-class | Class "OptimizationAlgorithm" |

Optimization-class | Class "Optimization" |

optimize | Optimize a design. |

parametersForComputingGradient | Define the parameters for computing the gradients of a model. |

PFIM-package | Fisher Information matrix for design evaluation/optimization... |

PFIMProject-class | Class "PFIMProject" |

PGBOAlgorithm-class | Class "PGBOAlgorithm" |

plotEvaluation | Graphs of the results of the evaluation. |

PlotEvaluation-class | Class "PlotEvaluation" |

plotFrequencies | Graph of the frequencies for the FW algorithm. |

plotOutcomesEvaluation | plotOutcomesEvaluation |

plotOutcomesGradient | plotOutcomesGradient |

plotRSE | Graph of the RSE. |

plotSE | Graph the SE. |

plotSensitivityIndice | Graphs of the results of the evaluation. |

plotShrinkage | Graph of the shrinkage. |

plotWeights | Graph of the weights for the multiplicative algorithm. |

PopulationFim-class | Class "PopulationFim" |

Proportional-class | Class "Proportional" |

PSOAlgorithm-class | Class "PSOAlgorithm" |

Report | Report |

reportTablesAdministration | reportTablesAdministration |

reportTablesDesign | reportTablesDesign |

reportTablesFIM | Generate the tables for the report. |

reportTablesModelError | Generate the tables for model errors for the evaluation... |

reportTablesModelParameters | Generate the tables for model parameters for the evaluation... |

reportTablesPlot | reportTablesPlot |

reportTablesSamplingConstraints | reportTablesSamplingConstraints |

resizeFisherMatrix | Resize the fisher Matrix from a vector to a matrix. |

run | run |

SamplingTimeConstraints-class | Class "SamplingTimeConstraints" |

SamplingTimes-class | Class "SamplingTimes" |

setAdministrations | setAdministrations |

setArm | setArm |

setArms | Set the arms of an object. |

setcError | Set the parameter c. |

setContent | Set content of a library of models. |

setDerivatives | Set the derivatives of the model error equation. |

setDescription | Set the description of a model. |

setDesigns | Set the designs. |

setDistribution | Set the distribution. |

setDose | Set the amount of dose |

setEquation | Set the equation of a model error. |

setEquations | Set the equations of a model. |

setEquationsAfterInfusion | Set the equations after infusion. |

setEquationsDuringInfusion | Set the equations during infusion. |

setEvaluationFIMResults | Set the evaluation results. |

setEvaluationInitialDesignResults | Set the evaluation results of the initial design. |

setFim | setFim |

setFimTypeToString | Convert the type of the object fim to a string. |

setFisherMatrix | Set the FIM. |

setFixedEffects | Set the fixed effects. |

setFixedMu | Set the mu as fixed or not. |

setFixedOmega | Set the omega as fixed of not. |

setInitialConditions | setInitialConditions |

setIterationAndCriteria | Set the iteration with the convergence criteria. |

setModel | Set the model. |

setModelError | Set the model error. |

setModelFromLibrary | Set a model from the library of model |

setMu | Set the value of the fixed effect mu of an object. |

setName | Set the name of an object. |

setNumberOfArms | setNumberOfArms |

setOdeSolverParameters | Set the parameters of the ode solver. |

setOmega | Set the matrix omega of an object. |

setOptimalDesign | Set the optimal design. |

setOptimalWeights | Set the optimal weights. |

setOptimizationResults | Set the optimization results. |

setOutcome | setOutcome |

setOutcomes | Set the outcomes of a model. |

setOutcomesEvaluation | setOutcomesEvaluation |

setOutcomesForEvaluation | Set the outcomes of a model used for the evaluation (is... |

setOutcomesGradient | setOutcomesGradient |

setParameters | Set the parameters of an object. |

setSamplingConstraintForOptimization | setSamplingConstraintForOptimization |

setSamplings | Set the sampling times. |

setSamplingTime | setSamplingTime |

setSamplingTimes | setSamplingTimes |

setSamplingTimesConstraints | setSamplingTimesConstraints |

setShrinkage | Set the shrinkage. |

setSigmaInter | Set the parameter sigma inter. |

setSigmaSlope | Set the parameter sigma slope. |

setSize | setSize |

setTau | setTau |

setTimeDose | setTimeDose |

setTinf | Set the infusion duration. |

setVarianceEffects | Set the matrix of the variance effects. |

show | show |

SimplexAlgorithm-class | Class "SimplexAlgorithm" |

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