generate_data: Simulated data

In PRIMEplus: Study Design for Immunotherapy Clinical Trials

Simulated data

Description

Generate simulated data

Usage

 
generate_data(N=500, rand_ratio=0.5, effect_p=0.6, enroll_rate=380*0.25/6, 
              lambda1=0.117, HR=0.5, tau=12*5, t1=1)

Arguments

N	Maximum sample size
rand_ratio	Allocation ratio
effect_p	Vector for proportion of responders in the treatment arm at baseline (see details)
enroll_rate	Enrollment rate in subjects per month
lambda1	Baseline hazard in terms of months
HR	Vector of hazard ratios for responders against controls (see details)
tau	Total study duration
t1	Delayed duration

Details

The length and order of effect_p must be the same as HR. Both of these vectors should contain information only for the groups of responders. For example, if there are full responders and partial responders, then effect_p and HR would be vectors of length two.

Value

A data frame with columns:

Name	Description
id	id variable
trt	treatment allocation: 1 = treatment arm
D1	patient's response status for group 1
D2	patient's response status for group 2
Dm	patient's response status for non-responders
tau	total study duration
enroll_time	patients' enrollment times
time_to_event	patients' event times
event_status	censoring indicator
X	observational time
t1	delayed duration

Author(s)

Zhenzhen Xu <[e-mail]>, Yongsoek Park <[e-mail]> and Bin Zhu <[e-mail]>

Examples

  data <- generate_data()
  data[1:5, ]

PRIMEplus documentation built on May 29, 2024, 11:56 a.m.