The package can prioritize the candidate disease metabolites based on the assumption that functionally related metabolites tend to associate with the same or similar diseases in the context of metabolic pathway. The PROFANCY package (1) prioritizes the disease metabolites from global functional similarity and local modularity of the metabolic network; (2) allows users to select default metabolites or input their interested metabolites as seed nodes or candidate nodes (3) can prioritize the candidate metabolites in KEGG or EHMN metabolic network.
|Author||Qianlan Yao, Desi Shang, Chunquan Li|
|Date of publication||2013-07-12 08:58:53|
|Maintainer||Qianlan Yao <firstname.lastname@example.org>|
|License||GPL (>= 2)|
aaa-PROFANCY-package: The PROFANCY package
envData: The variables in the environment variable envData of the...
getCandidates: Get candidate metabolites
getProvidedDiseaseName: Get all disease names provided by PROFANCY package
getSeed: Get seed metabolites
getTopDiseaseMetabolites: Get the disease Risk metabolites
initializeData: initialize environment envData
PROFANCY-internal: PROFANCY internal functions