Functions for fitting linear and nonlinear mixedeffects models using stochastic differential equations (SDEs). The package allows for any multivariate nonlinear timevariant model to be specified, and it also handles multidimensional input, covariates, missing observations, and specification of dosage regimen. The provided pipeline relies on the coupling of the FOCE algorithm and Kalman filtering as outlined by Klim et al (2009, <doi:10.1016/j.cmpb.2009.02.001>) and has been validated against the proprietary software 'NONMEM' (Tornoe et al, 2005, <doi:10.1007/s1109500552695>). Further functions are provided for finding smoothed estimates of model states and for simulation.
Package details 


Author  Stig Bousgaard Mortensen, Soeren Klim, Robert Miller 
Maintainer  Robert Miller <[email protected]> 
License  GPL (>= 2) 
Version  0.812 
URL  http://www.imm.dtu.dk/psm 
Package repository  View on CRAN 
Installation 
Install the latest version of this package by entering the following in R:

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