PSM: Non-Linear Mixed-Effects Modelling using Stochastic Differential Equations
Version 0.8-11

Functions for fitting linear and non-linear mixed-effects models using stochastic differential equations (SDEs). The provided pipeline relies on the coupling of the FOCE algorithm and Kalman filtering as outlined by Klim et al (2009) and has been validated against the proprietary software NONMEM (Tornøe et al, 2005, ). Further functions are provided for finding smoothed estimates of model states and for simulation. The package allows for any multivariate non-linear time-variant model to be specified, and it also handles multidimensional input, covariates, missing observations, and specification of dosage regimen.

Package details

AuthorStig Bousgaard Mortensen <[email protected]>, Søren Klim <[email protected]>
Date of publication2017-11-03 16:08:29
MaintainerRobert Miller <[email protected]>
LicenseGPL (>= 2)
Package repositoryView on CRAN
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PSM documentation built on Nov. 17, 2017, 5:05 a.m.