Description Usage Arguments References Examples

View source: R/ReturnMeansAgent.R

Returns the dose specific mean survival times for given efficacy and toxicity dose probability vector, distribution family and linear relationship between dose, effiacy, toxicity and survival.

1 | ```
ReturnMeansAgent(PE, PT, beta, Dose, Family, alpha)
``` |

`PE` |
True efficacy dose-toxicity vector. |

`PT` |
True toxicity dose-toxicity vector. |

`beta` |
True linear term for the rate or mean parameter |

`Dose` |
Vector of standardized doses considered in the trial. |

`Family` |
Time to event distribution. Options include: Exponential, Gamma, Weibull, Lognormal. |

`alpha` |
Shape parameter or standard deviation of a lognormal distribution. |

[1] Chapple and Thall (2018). A Hybrid Phase 12/3 Clinical Trial Design Allowing Dose Re-Optimization in Phase 3 Biometrics. Under Review.

1 2 3 4 5 6 7 8 9 10 11 12 13 | ```
##True Efficacy and Toxicity Probabilities
PT = c(.1,.15,.25,.35,.5)
PE=c(.2,.4,.6,.65,.7)
##Dose Levels considered
Dose = c(1,2,3,3.5,5)
Dose=(Dose-mean(Dose))/sd(Dose)
###Family of Distributions
Family="Gamma"
###Shape parameter ## Doesn't matter for exponential distribution
alpha=2
###True Beta vector
beta = c(.75,-.5, .3, -.25,2.143)
ReturnMeansAgent(PE,PT,beta,Dose,Family,alpha)
``` |

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