lr_db: Ligand-Receptor Pair Database

In PopComm: Population-Level Cell-Cell Communication Analysis Tools

Ligand-Receptor Pair Database

Description

A comprehensive database of human ligand-receptor pairs with gene/protein identifiers and supporting evidence from literature. Data imported from human_lr_pair.txt.

Usage

lr_db

Format

A data frame with 3,398 rows (pairs) and 10 columns:

lr_pair

Character. Unique identifier for ligand-receptor pair, formatted as "LIGAND_RECEPTOR" (e.g., "SEMA3F_PLXNA3")

ligand_gene_symbol

Character. Official HGNC symbol of the ligand gene (e.g., "SEMA3F")

receptor_gene_symbol

Character. Official HGNC symbol of the receptor gene (e.g., "PLXNA3")

ligand_gene_id

Integer. Entrez Gene ID of the ligand gene (NCBI identifier)

receptor_gene_id

Integer. Entrez Gene ID of the receptor gene (NCBI identifier)

ligand_ensembl_protein_id

Character. Ensembl protein ID of the ligand (e.g., "ENSP00000002829")

receptor_ensembl_protein_id

Character. Ensembl protein ID of the receptor (e.g., "ENSP00000358696")

ligand_ensembl_gene_id

Character. Ensembl gene ID of the ligand (e.g., "ENSG00000001617")

receptor_ensembl_gene_id

Character. Ensembl gene ID of the receptor (e.g., "ENSG00000130827")

evidence

Character. PubMed IDs (PMIDs) supporting the interaction, comma-separated (e.g., "15721238")

Source

Source from CellTalkDB (PMID: 33147626).

PopComm documentation built on June 8, 2025, 1:45 p.m.