PwrGSD: Power in a Group Sequential Design

Tools the evaluation of interim analysis plans for sequentially monitored trials on a survival endpoint; tools to construct efficacy and futility boundaries, for deriving power of a sequential design at a specified alternative, template for evaluating the performance of candidate plans at a set of time varying alternatives.

Author
Grant Izmirlian
Date of publication
2014-03-21 07:13:42
Maintainer
Grant Izmirlian <izmirlig@mail.nih.gov>
License
GPL (>= 2)
Version
2.000

View on CRAN

Man pages

Ch01-PwrGSD
Calculate Power in a Group Sequential Design
Ch02-LanDemets
The Lan-Demets method of Boundary Construction
Ch03-ObrienFleming
The O'Brien-Fleming Alpha Spending Function
Ch04-Pow
The Wang-Tsiatis Power Alpha Spending Function
Ch05-Pocock
The Pocock Alpha Spending Function
Ch06-SC
The Stochastic Curtailment method of Boundary Construction
Ch07-Haybittle
The Haybittle method of Boundary Construction
Ch08-cpd.PwrGSD
Create a skeleton compound PwrGSD object
Ch09-Power
Extract the Power results
Ch0A-as.boundaries
Convert a "PwrGSD" object to a "boundaries" object
Ch0B-Elements
Create a subset of a "cpd.PwrGSD" object
Ch0C-plot.cpd.PwrGSD
Plot Method for cpd.PwrGSD objects
Ch0D-GrpSeqBnds
Computes efficacy and futility boundaries
Ch0E-CondPower
Conditional type I and type II error probabilities given...
Ch0F-SimGSB
Verifies the results of "GrpSeqBnds" via simulation
Ch10-wtdlogrank
Weighted log-rank test
Ch11-IntSurvDiff
Weighted Integrated Survival function test
Ch12-agghaz
Aggregated Hazard
Ch13-mysurvfit
My Survfit
Ch14-mystack
Stack a dataset
Ch15-CDFOR2LRR
Convert CDF Odds Ratio to Logged Relative Risks
Ch16-CY2TOShaz
Calender year rates to Study Year Rates
Ch17-CRRtoRR
Cumulative-risk ratios to risk ratios
Ch18-RCM2RR
Relative cumulative mortality to Relative Risk
Ch19-RR2RCM
Relative risk to Relative Cumulative Mortality
Ch1A-lookup
Lookup values for a piecewise constant function
Ch1B-lung
Mayo Clinic Lung Cancer Data
Ch1C-DX
A utility function for forming differences
Ch1D-pste
The paste operator
Ch1E-SCtoBdry
Converts a stochastic curtailment boundary (conditional type...
Ch1F-gsddens
A function for computing the probability density for the...
Ch20-EX1gXK
A function for computing the bias adjusted point estimate for...

Files in this package

PwrGSD
PwrGSD/inst
PwrGSD/inst/doc
PwrGSD/inst/doc/PwrGSD-vignette.R
PwrGSD/inst/doc/PwrGSD-vignette.Rnw
PwrGSD/inst/doc/GrpSeqBnds-vignette.Rnw
PwrGSD/inst/doc/cpd-PwrGSD-vignette.R
PwrGSD/inst/doc/GrpSeqBnds-vignette.R
PwrGSD/inst/doc/PwrGSD-vignette.pdf
PwrGSD/inst/doc/GrpSeqBnds-vignette.pdf
PwrGSD/inst/doc/PwrGSD-manual.pdf
PwrGSD/inst/doc/cpd-PwrGSD-vignette.Rnw
PwrGSD/inst/doc/cpd-PwrGSD-vignette.pdf
PwrGSD/src
PwrGSD/src/WtdLogRank.c
PwrGSD/src/mystack.c
PwrGSD/src/rao-blackwell.c
PwrGSD/src/AsyPwrGSD.c
PwrGSD/src/SimPwrGSD.c
PwrGSD/src/drift.c
PwrGSD/src/projectend.c
PwrGSD/src/agghaz.c
PwrGSD/src/cmptpwrgsd.c
PwrGSD/src/lookup.c
PwrGSD/src/trand.c
PwrGSD/src/cpblocked.c
PwrGSD/src/intsurvdiff.c
PwrGSD/src/mysurvfit.c
PwrGSD/src/StCu2Bnds.c
PwrGSD/src/myapprox.c
PwrGSD/src/Finv.c
PwrGSD/src/driftfu.c
PwrGSD/src/htilde.c
PwrGSD/src/grpseqbnds.c
PwrGSD/NAMESPACE
PwrGSD/data
PwrGSD/data/lung.rda
PwrGSD/R
PwrGSD/R/PwrGSD.R
PwrGSD/R/mysurvfit.R
PwrGSD/vignettes
PwrGSD/vignettes/PwrGSD-vignette.Rnw
PwrGSD/vignettes/GrpSeqBnds-vignette.Rnw
PwrGSD/vignettes/cpd-PwrGSD-vignette.Rnw
PwrGSD/MD5
PwrGSD/build
PwrGSD/build/vignette.rds
PwrGSD/DESCRIPTION
PwrGSD/man
PwrGSD/man/Ch17-CRRtoRR.Rd
PwrGSD/man/Ch1D-pste.Rd
PwrGSD/man/Ch19-RR2RCM.Rd
PwrGSD/man/Ch12-agghaz.Rd
PwrGSD/man/Ch15-CDFOR2LRR.Rd
PwrGSD/man/Ch0F-SimGSB.Rd
PwrGSD/man/Ch0D-GrpSeqBnds.Rd
PwrGSD/man/Ch20-EX1gXK.Rd
PwrGSD/man/Ch11-IntSurvDiff.Rd
PwrGSD/man/Ch02-LanDemets.Rd
PwrGSD/man/Ch14-mystack.Rd
PwrGSD/man/Ch01-PwrGSD.Rd
PwrGSD/man/Ch04-Pow.Rd
PwrGSD/man/Ch13-mysurvfit.Rd
PwrGSD/man/Ch1B-lung.Rd
PwrGSD/man/Ch0A-as.boundaries.Rd
PwrGSD/man/Ch0C-plot.cpd.PwrGSD.Rd
PwrGSD/man/Ch1E-SCtoBdry.Rd
PwrGSD/man/Ch08-cpd.PwrGSD.Rd
PwrGSD/man/Ch1C-DX.Rd
PwrGSD/man/Ch1A-lookup.Rd
PwrGSD/man/Ch1F-gsddens.Rd
PwrGSD/man/Ch0E-CondPower.Rd
PwrGSD/man/Ch0B-Elements.Rd
PwrGSD/man/Ch03-ObrienFleming.Rd
PwrGSD/man/Ch07-Haybittle.Rd
PwrGSD/man/Ch06-SC.Rd
PwrGSD/man/Ch16-CY2TOShaz.Rd
PwrGSD/man/Ch09-Power.Rd
PwrGSD/man/Ch10-wtdlogrank.Rd
PwrGSD/man/Ch18-RCM2RR.Rd
PwrGSD/man/Ch05-Pocock.Rd