PwrGSD: Power in a Group Sequential Design

Tools the evaluation of interim analysis plans for sequentially monitored trials on a survival endpoint; tools to construct efficacy and futility boundaries, for deriving power of a sequential design at a specified alternative, template for evaluating the performance of candidate plans at a set of time varying alternatives.

AuthorGrant Izmirlian
Date of publication2014-03-21 07:13:42
MaintainerGrant Izmirlian <izmirlig@mail.nih.gov>
LicenseGPL (>= 2)
Version2.000

View on CRAN

Man pages

Ch01-PwrGSD: Calculate Power in a Group Sequential Design

Ch02-LanDemets: The Lan-Demets method of Boundary Construction

Ch03-ObrienFleming: The O'Brien-Fleming Alpha Spending Function

Ch04-Pow: The Wang-Tsiatis Power Alpha Spending Function

Ch05-Pocock: The Pocock Alpha Spending Function

Ch06-SC: The Stochastic Curtailment method of Boundary Construction

Ch07-Haybittle: The Haybittle method of Boundary Construction

Ch08-cpd.PwrGSD: Create a skeleton compound PwrGSD object

Ch09-Power: Extract the Power results

Ch0A-as.boundaries: Convert a "PwrGSD" object to a "boundaries" object

Ch0B-Elements: Create a subset of a "cpd.PwrGSD" object

Ch0C-plot.cpd.PwrGSD: Plot Method for cpd.PwrGSD objects

Ch0D-GrpSeqBnds: Computes efficacy and futility boundaries

Ch0E-CondPower: Conditional type I and type II error probabilities given...

Ch0F-SimGSB: Verifies the results of "GrpSeqBnds" via simulation

Ch10-wtdlogrank: Weighted log-rank test

Ch11-IntSurvDiff: Weighted Integrated Survival function test

Ch12-agghaz: Aggregated Hazard

Ch13-mysurvfit: My Survfit

Ch14-mystack: Stack a dataset

Ch15-CDFOR2LRR: Convert CDF Odds Ratio to Logged Relative Risks

Ch16-CY2TOShaz: Calender year rates to Study Year Rates

Ch17-CRRtoRR: Cumulative-risk ratios to risk ratios

Ch18-RCM2RR: Relative cumulative mortality to Relative Risk

Ch19-RR2RCM: Relative risk to Relative Cumulative Mortality

Ch1A-lookup: Lookup values for a piecewise constant function

Ch1B-lung: Mayo Clinic Lung Cancer Data

Ch1C-DX: A utility function for forming differences

Ch1D-pste: The paste operator

Ch1E-SCtoBdry: Converts a stochastic curtailment boundary (conditional type...

Ch1F-gsddens: A function for computing the probability density for the...

Ch20-EX1gXK: A function for computing the bias adjusted point estimate for...

Functions

\%,\% Man page
agghaz Man page
as.boundaries Man page
CDFOR2LRR Man page
CondPower Man page
cpd.PwrGSD Man page
CRRtoRR Man page
CY2TOShaz Man page
DX Man page
Elements Man page
EX1gXK Man page
GrpSeqBnds Man page
gsd.dens Man page
Haybittle Man page
IntSurvDiff Man page
LanDemets Man page
lookup Man page
lung Man page
mystack Man page
mysurvfit Man page
ObrienFleming Man page
paste Man page
plot.cpd.PwrGSD Man page
Pocock Man page
Pow Man page
Power Man page
PwrGSD Man page
RCM2RR Man page
RR2RCM Man page
SC Man page
SCtoBdry Man page
SimGSB Man page
wtdlogrank Man page

Files

PwrGSD
PwrGSD/inst
PwrGSD/inst/doc
PwrGSD/inst/doc/PwrGSD-vignette.R
PwrGSD/inst/doc/PwrGSD-vignette.Rnw
PwrGSD/inst/doc/GrpSeqBnds-vignette.Rnw
PwrGSD/inst/doc/cpd-PwrGSD-vignette.R
PwrGSD/inst/doc/GrpSeqBnds-vignette.R
PwrGSD/inst/doc/PwrGSD-vignette.pdf
PwrGSD/inst/doc/GrpSeqBnds-vignette.pdf
PwrGSD/inst/doc/PwrGSD-manual.pdf
PwrGSD/inst/doc/cpd-PwrGSD-vignette.Rnw
PwrGSD/inst/doc/cpd-PwrGSD-vignette.pdf
PwrGSD/src
PwrGSD/src/WtdLogRank.c
PwrGSD/src/mystack.c
PwrGSD/src/rao-blackwell.c
PwrGSD/src/AsyPwrGSD.c
PwrGSD/src/SimPwrGSD.c
PwrGSD/src/drift.c
PwrGSD/src/projectend.c
PwrGSD/src/agghaz.c
PwrGSD/src/cmptpwrgsd.c
PwrGSD/src/lookup.c
PwrGSD/src/trand.c
PwrGSD/src/cpblocked.c
PwrGSD/src/intsurvdiff.c
PwrGSD/src/mysurvfit.c
PwrGSD/src/StCu2Bnds.c
PwrGSD/src/myapprox.c
PwrGSD/src/Finv.c
PwrGSD/src/driftfu.c
PwrGSD/src/htilde.c
PwrGSD/src/grpseqbnds.c
PwrGSD/NAMESPACE
PwrGSD/data
PwrGSD/data/lung.rda
PwrGSD/R
PwrGSD/R/PwrGSD.R PwrGSD/R/mysurvfit.R
PwrGSD/vignettes
PwrGSD/vignettes/PwrGSD-vignette.Rnw
PwrGSD/vignettes/GrpSeqBnds-vignette.Rnw
PwrGSD/vignettes/cpd-PwrGSD-vignette.Rnw
PwrGSD/MD5
PwrGSD/build
PwrGSD/build/vignette.rds
PwrGSD/DESCRIPTION
PwrGSD/man
PwrGSD/man/Ch17-CRRtoRR.Rd PwrGSD/man/Ch1D-pste.Rd PwrGSD/man/Ch19-RR2RCM.Rd PwrGSD/man/Ch12-agghaz.Rd PwrGSD/man/Ch15-CDFOR2LRR.Rd PwrGSD/man/Ch0F-SimGSB.Rd PwrGSD/man/Ch0D-GrpSeqBnds.Rd PwrGSD/man/Ch20-EX1gXK.Rd PwrGSD/man/Ch11-IntSurvDiff.Rd PwrGSD/man/Ch02-LanDemets.Rd PwrGSD/man/Ch14-mystack.Rd PwrGSD/man/Ch01-PwrGSD.Rd PwrGSD/man/Ch04-Pow.Rd PwrGSD/man/Ch13-mysurvfit.Rd PwrGSD/man/Ch1B-lung.Rd PwrGSD/man/Ch0A-as.boundaries.Rd PwrGSD/man/Ch0C-plot.cpd.PwrGSD.Rd PwrGSD/man/Ch1E-SCtoBdry.Rd PwrGSD/man/Ch08-cpd.PwrGSD.Rd PwrGSD/man/Ch1C-DX.Rd PwrGSD/man/Ch1A-lookup.Rd PwrGSD/man/Ch1F-gsddens.Rd PwrGSD/man/Ch0E-CondPower.Rd PwrGSD/man/Ch0B-Elements.Rd PwrGSD/man/Ch03-ObrienFleming.Rd PwrGSD/man/Ch07-Haybittle.Rd PwrGSD/man/Ch06-SC.Rd PwrGSD/man/Ch16-CY2TOShaz.Rd PwrGSD/man/Ch09-Power.Rd PwrGSD/man/Ch10-wtdlogrank.Rd PwrGSD/man/Ch18-RCM2RR.Rd PwrGSD/man/Ch05-Pocock.Rd

Questions? Problems? Suggestions? or email at ian@mutexlabs.com.

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