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#' IST Dataset
#'
#' The International Stroke Trial Dataset
#'
#' Obtained from
#' Sandercock, Peter; Niewada, Maciej; Czlonkowska, Anna. (2011).
#' International Stroke Trial database (version 2), \[dataset\].
#' University of Edinburgh. Department of Clinical Neurosciences.
#' \doi{https://doi.org/10.7488/ds/104}
#' Under ODC-by licence
#'
#' @format A data frame with 19435 rows and 112 columns:
#' \describe{
#' \item{AGE}{Randomisation data: Age in years}
#' \item{CMPLASP}{Other data and derived variables: Compliant for aspirin}
#' \item{CMPLHEP}{Other data and derived variables: Compliant for heparin}
#' \item{CNTRYNUM}{Other data and derived variables: Country code}
#' \item{COUNTRY}{Other data and derived variables: Abbreviated country code}
#' \item{DALIVE}{Recurrent stroke within 14 days:
#' Discharged alive from hospital}
#' \item{DALIVED}{Recurrent stroke within 14 days:
#' Date Discharged alive from hospital}
#' \item{DAP}{Data collected on 14 day/discharge form
#' about treatments given in hospital: Non trial antiplatelet drug (Y/N)}
#' \item{DASP14}{Data collected on 14 day/discharge form
#' about treatments given in hospital: Aspirin given for 14 days
#' or till death or discharge (Y/N)}
#' \item{DASPLT}{Data collected on 14 day/discharge form
#' about treatments given in hospital: Discharged on long term aspirin (Y/N)}
#' \item{DAYLOCAL}{Randomisation data: Estimate of local day of week
#' (assuming RDATE is Oxford)}
#' \item{DCAA}{Data collected on 14 day/discharge form
#' about treatments given in hospital: Calcium antagonists (Y/N)}
#' \item{DCAREND}{Data collected on 14 day/discharge form
#' about treatments given in hospital: Carotid surgery (Y/N)}
#' \item{DDEAD}{Other events within 14 days:
#' Dead on discharge form}
#' \item{DDEADC}{Other events within 14 days: Cause of death
#' (1-Initial stroke/2-Recurrent stroke (ischaemic or unknown
#' /3-Recurrent stroke (haemorrhagic)/4-Pneumonia
#' /5-Coronary heart disease/6-Pulmonary embolism
#' /7-Other vascular or unknown/8-Non-vascular/0-unknown)}
#' \item{DDEADD}{Date of dead on discharge form (yyyy/mm/dd);
#' NOTE: this death is not necessarily within 14 days of randomisation}
#' \item{DDEADX}{Other events within 14 days: Comment on death}
#' \item{DDIAGHA}{Final diagnosis of initial event: Haemorrhagic stroke}
#' \item{DDIAGISC}{Final diagnosis of initial event: Ischaemic stroke}
#' \item{DDIAGUN}{Final diagnosis of initial event: Indeterminate stroke}
#' \item{DEAD1}{Indicator variables for specific causes of death:
#' Initial stroke}
#' \item{DEAD2}{Indicator variables for specific causes of death:
#' Reccurent ischaemic/unknown stroke}
#' \item{DEAD3}{Indicator variables for specific causes of death:
#' Reccurent haemorrhagic stroke}
#' \item{DEAD4}{Indicator variables for specific causes of death:
#' Pneumonia}
#' \item{DEAD5}{Indicator variables for specific causes of death:
#' Coronary heart disease}
#' \item{DEAD6}{Indicator variables for specific causes of death:
#' Pulmonary embolism}
#' \item{DEAD7}{Indicator variables for specific causes of death:
#' Other vascular or unknown}
#' \item{DEAD8}{Indicator variables for specific causes of death:
#' Non vascular}
#' \item{DGORM}{Data collected on 14 day/discharge form
#' about treatments given in hospital: Glycerol or manitol (Y/N)}
#' \item{DHAEMD}{Data collected on 14 day/discharge form
#' about treatments given in hospital: Haemodilution (Y/N)}
#' \item{DHH14}{Data collected on 14 day/discharge form
#' about treatments given in hospital: Medium dose heparin given for 14 days
#' etc in pilot (combine with above)}
#' \item{DIED}{Other data and derived variables: Indicator variable for death
#' (1=died; 0=did not die)}
#' \item{DIVH}{Data collected on 14 day/discharge form
#' about treatments given in hospital: Non trial intravenous heparin (Y/N)}
#' \item{DLH14}{Data collected on 14 day/discharge form
#' about treatments given in hospital: Low dose heparin given for 14 days
#' or till death/discharge (Y/N)}
#' \item{DMAJNCH}{Data collected on 14 day/discharge form
#' about treatments given in hospital: Major non-cerebral haemorrhage (Y/N)}
#' \item{DMAJNCHD}{Data collected on 14 day/discharge form
#' about treatments given in hospital:
#' Date of Major non-cerebral haemorrhage (yyyy/mm/dd)}
#' \item{DMAJNCHX}{Data collected on 14 day/discharge form
#' about treatments given in hospital:
#' Comment of Major non-cerebral haemorrhage}
#' \item{DMH14}{Data collected on 14 day/discharge form
#' about treatments given in hospital: Date of Major non-cerebral haemorrhage
#' (yyyy/mm/dd)}
#' \item{DNOSTRK}{Final diagnosis of initial event: Not a stroke}
#' \item{DNOSTRKX}{Final diagnosis of initial event: Comment on Not a stroke}
#' \item{DOAC}{Data collected on 14 day/discharge form
#' about treatments given in hospital: Other anticoagulants (Y/N)}
#' \item{DPE}{Other events within 14 days: Pulmonary embolism}
#' \item{DPED}{Other events within 14 days:
#' Date of Pulmonary embolism (yyyy/mm/dd)}
#' \item{DPLACE}{Other events within 14 days: Discharge destination
#' (A-Home
#' /B-Relatives home
#' /C-Residential care
#' /D-Nursing home
#' /E-Other hospital departments
#' /U-Unknown)}
#' \item{DRSH}{Recurrent stroke within 14 days: Haemorrhagic stroke}
#' \item{DRSHD}{Recurrent stroke within 14 days:
#' Date of Haemorrhagic stroke (yyyy/mm/dd)}
#' \item{DRSISC}{Recurrent stroke within 14 days: Ischaemic recurrent stroke}
#' \item{DRSISCD}{Recurrent stroke within 14 days:
#' Date of Ischaemic recurrent stroke (yyyy/mm/dd)}
#' \item{DRSUNK}{Recurrent stroke within 14 days: Unknown type}
#' \item{DRSUNKD}{Recurrent stroke within 14 days:
#' Date of Unknown type (yyyy/mm/dd)}
#' \item{DSCH}{Data collected on 14 day/discharge form
#' about treatments given in hospital: Non trial subcutaneous heparin (Y/N)}
#' \item{DSIDE}{Data collected on 14 day/discharge form
#' about treatments given in hospital: Other side effect (Y/N)}
#' \item{DSIDED}{Data collected on 14 day/discharge
#' form about treatments given in hospital: Date of Other side effect}
#' \item{DSIDEX}{Data collected on 14 day/discharge form
#' about treatments given in hospital: Comment of Other side effect}
#' \item{DSTER}{Data collected on 14 day/discharge form
#' about treatments given in hospital: Steroids (Y/N)}
#' \item{DTHROMB}{Data collected on 14 day/discharge form
#' about treatments given in hospital: Thrombolysis (Y/N)}
#' \item{DVT14}{Indicator variables for specific causes of death:
#' Indicator of deep vein thrombosis on discharge form}
#' \item{EXPD14}{Other data and derived variables:
#' Predicted probability of death at 14 days}
#' \item{EXPD6}{Other data and derived variables:
#' Predicted probability of death at 6 month}
#' \item{EXPDD}{Other data and derived variables:
#' Predicted probability of death/dependence at 6 month}
#' \item{FAP}{Data collected at 6 months: On antiplatelet drugs}
#' \item{FDEAD}{Data collected at 6 months: Dead at six month follow-up (Y/N)}
#' \item{FDEADC}{Data collected at 6 months: Cause of death (1-Initial stroke
#' /2-Recurrent stroke (ischaemic or unknown)
#' /3-Recurrent stroke (haemorrhagic)
#' /4-Pneumonia
#' /5-Coronary heart disease
#' /6-Pulmonary embolism
#' /7-Other vascular or unknown
#' /8-Non-vascular
#' /0-unknown)}
#' \item{FDEADD}{Data collected at 6 months: Date of death;
#' NOTE: this death is not necessarily within 6 months of randomisation}
#' \item{FDEADX}{Data collected at 6 months: Comment on death}
#' \item{FDENNIS}{Data collected at 6 months:
#' Dependent at 6 month follow-up (Y/N)}
#' \item{FLASTD}{Data collected at 6 months: Date of last contact}
#' \item{FOAC}{Data collected at 6 months: On anticoagulants}
#' \item{FPLACE}{Data collected at 6 months:
#' Place of residance at 6 month follow-up (
#' A-Home
#' /B-Relatives home
#' /C-Residential care
#' /D-Nursing home
#' /E-Other hospital departments
#' /U-Unknown)}
#' \item{FRECOVER}{Data collected at 6 months:
#' Fully recovered at 6 month follow-up (Y/N)}
#' \item{FU1_COMP}{Other data and derived variables:
#' Date discharge form completed}
#' \item{FU1_RECD}{Other data and derived variables:
#' Date discharge form received}
#' \item{FU2_DONE}{Other data and derived variables:
#' Date 6 month follow-up done}
#' \item{H14}{Indicator variables for specific causes of death:
#' Cerebral bleed/heamorrhagic stroke within 14 days;
#' this is slightly wider definition than DRSH an is used for analysis of
#' cerebral bleeds}
#' \item{HOSPNUM}{Randomisation data: Hospital number}
#' \item{HOURLOCAL}{Randomisation data: Local time – hours}
#' \item{HTI14}{Indicator variables for specific causes of death:
#' Indicator of haemorrhagic transformation within 14 days}
#' \item{ID14}{Other data and derived variables:
#' Indicator of death at 14 days}
#' \item{ISC14}{Indicator variables for specific causes of death:
#' Indicator of ischaemic stroke within 14 days}
#' \item{MINLOCAL}{Randomisation data: Local time – minutes}
#' \item{NCB14}{Indicator variables for specific causes of death:
#' Indicator of any non-cerebral bleed within 14 days}
#' \item{NCCODE}{Other data and derived variables:
#' Coding of compliance
#' (see Table 3) \doi{10.1186/1745-6215-13-24}}
#' \item{NK14}{Indicator variables for specific causes of death:
#' Indicator of indeterminate stroke within 14 days}
#' \item{OCCODE}{Other data and derived variables:
#' Six month outcome (
#' 1-dead
#' /2-dependent
#' /3-not recovered
#' /4-recovered
#' /8 or 9 – missing status}
#' \item{ONDRUG}{Data collected on 14 day/discharge form
#' about treatments given in hospital:
#' Estimate of time in days on trial treatment}
#' \item{PE14}{Indicator variables for specific causes of death:
#' Indicator of pulmonary embolism within 14 days}
#' \item{RASP3}{Randomisation data:
#' Aspirin within 3 days prior to randomisation (Y/N)}
#' \item{RATRIAL}{Randomisation data:
#' Atrial fibrillation (Y/N); not coded for pilot phase - 984 patients}
#' \item{RCONSC}{Randomisation data:
#' Conscious state at randomisation
#' (F - fully alert, D - drowsy, U - unconscious)}
#' \item{RCT}{Randomisation data:
#' CT before randomisation (Y/N)}
#' \item{RDATE}{Randomisation data:
#' Date of randomisation}
#' \item{RDEF1}{Randomisation data:
#' Face deficit (Y/N/C=can't assess)}
#' \item{RDEF2}{Randomisation data:
#' Arm/hand deficit (Y/N/C=can't assess)}
#' \item{RDEF3}{Randomisation data:
#' Leg/foot deficit (Y/N/C=can't assess)}
#' \item{RDEF4}{Randomisation data:
#' Dysphasia (Y/N/C=can't assess)}
#' \item{RDEF5}{Randomisation data:
#' Hemianopia (Y/N/C=can't assess)}
#' \item{RDEF6}{Randomisation data:
#' Visuospatial disorder (Y/N/C=can't assess)}
#' \item{RDEF7}{Randomisation data:
#' Brainstem/cerebellar signs (Y/N/C=can't assess)}
#' \item{RDEF8}{Randomisation data:
#' Other deficit (Y/N/C=can't assess)}
#' \item{RDELAY}{Randomisation data:
#' Delay between stroke and randomisation in hours}
#' \item{RHEP24}{Randomisation data:
#' Heparin within 24 hours prior to randomisation (Y/N)}
#' \item{RSBP}{Randomisation data:
#' Systolic blood pressure at randomisation (mmHg)}
#' \item{RSLEEP}{Randomisation data:
#' Symptoms noted on waking (Y/N)}
#' \item{RVISINF}{Randomisation data:
#' Infarct visible on CT (Y/N)}
#' \item{RXASP}{Randomisation data:
#' Trial aspirin allocated (Y/N)}
#' \item{RXHEP}{Randomisation data:
#' Trial heparin allocated (M/L/N) \\[M is coded as H=high in pilot\\]}
#' \item{SET14D}{Other data and derived variables:
#' Know to be dead or alive at 14 days (1=Yes, 0=No);
#' this does not necessarily mean that we know outcome at 6 monts
#' – see OCCODE for this}
#' \item{SEX}{Randomisation data: M=male; F=female}
#' \item{STRK14}{Indicator variables for specific causes of death:
#' Indicator of any stroke within 14 days}
#' \item{STYPE}{Randomisation data: Stroke subtype (TACS/PACS/POCS/LACS/other)}
#' \item{TD}{Other data and derived variables:
#' Time of death or censoring in days}
#' \item{TRAN14}{Indicator variables for specific causes of death:
#' Indicator of major non-cerebral bleed within 14 days}
#' ...
#' }
#'
#' @author Sandercock P et al. \email{Peter.Sandercock@@ed.ac.uk}
#' @references \doi{10.7488/ds/104}
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