RNOmni: Rank Normal Transformation Omnibus Test

Inverse normal transformation (INT) based genetic association testing. These tests are recommend for continuous traits with non-normally distributed residuals. INT-based tests robustly control the type I error in settings where standard linear regression does not, as when the residual distribution exhibits excess skew or kurtosis. Moreover, INT-based tests dominate standard linear regression in terms of power. These tests may be classified into two types. In direct INT (D-INT), the phenotype is itself transformed. In indirect INT (I-INT), phenotypic residuals are transformed. The omnibus test (O-INT) adaptively combines D-INT and I-INT into a single robust and statistically powerful approach. See McCaw ZR, Lane JM, Saxena R, Redline S, Lin X. "Operating characteristics of the rank-based inverse normal transformation for quantitative trait analysis in genome-wide association studies" <doi:10.1111/biom.13214>.

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Package details

AuthorZachary McCaw [aut, cre] (<https://orcid.org/0000-0002-2006-9828>)
MaintainerZachary McCaw <zmccaw@alumni.harvard.edu>
Package repositoryView on CRAN
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RNOmni documentation built on Oct. 23, 2020, 5:55 p.m.