ROC632: Construction of diagnostic or prognostic scoring system and internal validation of its discriminative capacities based on ROC curve and 0.633+ boostrap resampling.

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This package computes traditional ROC curves and time-dependent ROC curves using the cross-validation, the 0.632 and the 0.632+ estimators. The 0.632+ estimator of time-dependent ROC curve is useful to estimate the predictive accuracy of prognostic signature based on high-dimensional data. For instance, it outperforms the other approaches, especially the cross-validation solution which is often used. The 0.632+ estimators correct the area under the curve in order to adequately estimate the prognostic capacities regardless of the overfitting level. This package also allows for the construction of diagnostic or prognostic scoring systems (penalized regressions). The methodology is adapted to complete data (penalized logistic regression associated with ROC curve) or incomplete time-to-event data (penalized Cox model associated with time-dependent ROC curve).

Author
Y. Foucher <Yohann.Foucher@univ-nantes.fr>
Date of publication
2013-12-27 22:22:51
Maintainer
Y. Foucher <Yohann.Foucher@univ-nantes.fr>
License
GPL (>= 2)
Version
0.6
URLs

View on CRAN

Man pages

AUC
Area under ROC curve from sensitivities and specificities
boot.ROC
Construction of a diagnostic or prognostic scoring system and...
boot.ROCt
Construction of a prognostic scoring system and estimation of...
DLBCLgenes
The data concerning the gene expressions of the DLBCL...
DLBCLpatients
The data concerning the clinical information of the DLBCL...
ROC
Estimation of the traditional ROC curves (without censoring)
ROC632-package
Estimation of prognostic capacity of microarray data.

Files in this package

ROC632
ROC632/NAMESPACE
ROC632/data
ROC632/data/DLBCLgenes.rda
ROC632/data/DLBCLpatients.rda
ROC632/data/datalist
ROC632/R
ROC632/R/prog.R
ROC632/MD5
ROC632/DESCRIPTION
ROC632/man
ROC632/man/ROC632-package.Rd
ROC632/man/DLBCLgenes.Rd
ROC632/man/boot.ROCt.Rd
ROC632/man/AUC.Rd
ROC632/man/DLBCLpatients.Rd
ROC632/man/ROC.Rd
ROC632/man/boot.ROC.Rd