rejectprob: Rejection Probability Calculation

In STARTdesign: Single to Double Arm Transition Design for Phase II Clinical Trials

Description

Calculate the probability of rejecting the null hypothesis at the end of the second stage in the Single-to-double Arm Transition Design

Usage

rejectprob(pe,ps,n1,n2,r1,z)

Arguments

pe	The response rate of the experimental arm.
ps	The response rate of the standard arm.
n1	The number of subjects in the experiemntal arm in the single-arm stage.
n2	The number of subjects in each arm in the double-arm stage.
r1	The minimum number of responses to achieve in the single-arm stage in order for the trial to proceed into the next stage.
z	The threshold value for the Z test, i.e., the Z statistic should be greater than z in order to reject the null hypothesis at the end of the second stage.

Value

n1	The number of subjects in the experiemntal arm in the single-arm stage.
n2	The number of subjects in each arm in the double-arm stage.
r1	The minimum number of responses to achieve in the single-arm stage in order for the trial to proceed into the next stage.The number of responses observed at the end of single-arm stage should be greater than or equal to r1 for the trial to proceed.
ess0	The expected sample size under the null hypothesis.
ess1	The expected sample size under the alternative hypothesis.
asn	The average sample number taken as the average of ess0 and ess1.

Author(s)

Haolun Shi <[e-mail]>,
Guosheng Yin <[e-mail]>

References

Shi H., Yin G. (2017), START: Single-to-double Arm Transition Design for Phase II Clinical Trials.

Examples

rejectprob(pe=0.2,ps=0.4,n1=20,n2=40,r1=10,z=qnorm(0.9))

STARTdesign documentation built on May 2, 2019, 3:01 a.m.