Description Usage Arguments Value Author(s) References Examples

Calculate the probability of rejecting the null hypothesis at the end of the second stage in the Single-to-double Arm Transition Design

1 | ```
rejectprob(pe,ps,n1,n2,r1,z)
``` |

`pe` |
The response rate of the experimental arm. |

`ps` |
The response rate of the standard arm. |

`n1` |
The number of subjects in the experiemntal arm in the single-arm stage. |

`n2` |
The number of subjects in each arm in the double-arm stage. |

`r1` |
The minimum number of responses to achieve in the single-arm stage in order for the trial to proceed into the next stage. |

`z` |
The threshold value for the Z test, i.e., the Z statistic should be greater than |

`n1` |
The number of subjects in the experiemntal arm in the single-arm stage. |

`n2` |
The number of subjects in each arm in the double-arm stage. |

`r1` |
The minimum number of responses to achieve in the single-arm stage in order for the trial to proceed into the next stage.The number of responses observed at the end of single-arm stage should be greater than or equal to |

`ess0` |
The expected sample size under the null hypothesis. |

`ess1` |
The expected sample size under the alternative hypothesis. |

`asn` |
The average sample number taken as the average of |

Haolun Shi <[email protected]>,

Guosheng Yin <[email protected]>

Shi H., Yin G. (2017), START: Single-to-double Arm Transition Design for Phase II Clinical Trials.

1 | ```
rejectprob(pe=0.2,ps=0.4,n1=20,n2=40,r1=10,z=qnorm(0.9))
``` |

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