SampleSize4ClinicalTrials: Sample Size Calculation for Mean and Proportion Comparisons in Phase 3 Clinical Trials

The design of phase 3 clinical trials can be classified into 4 types: (1) Testing for equality;(2) Superiority trial;(3) Non-inferiority trial; and (4) Equivalence trial according to the goals. Given that none of the available packages combines these designs in a single package, this package has made it possible for researchers to calculate sample size when comparing means or proportions in phase 3 clinical trials with different designs. The ssc function can calculate the sample size with pre-specified type 1 error rate,statistical power and effect size according to the hypothesis testing framework. Furthermore, effect size is comprised of true treatment difference and non-inferiority or equivalence margins which can be set in ssc function. (Reference: Yin, G. (2012). Clinical Trial Design: Bayesian and Frequentist Adaptive Methods. John Wiley & Sons.)

Getting started

Package details

AuthorHongchao Qi
MaintainerHongchao Qi <[email protected]>
Package repositoryView on CRAN
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SampleSize4ClinicalTrials documentation built on Sept. 17, 2017, 5:02 p.m.