ssc_propcomp: Sample Size Calculation for the Comparison of Proportions in...

In SampleSize4ClinicalTrials: Sample Size Calculation for the Comparison of Means or Proportions in Phase III Clinical Trials

Description

This function aims to calculate sample size for the comparison of proportions in Phase III clinical trials.

Usage

ssc_propcomp(design, ratio, alpha, power, p1, p2, delta)

Arguments

design	The design of the clinical trials. 1L Testing for equality 2L Superiority trial 3L Non-inferiority trial 4L Equivalence trial.
ratio	The ratio between the number of subjects in the treatment arm and that in the control arm.
alpha	Type I error rate
power	Statistical power of the test (1-type II error rate)
p1	The true mean response rate of the treatment arm
p2	The true mean response rate of the control arm
delta	The prespecified superiority, non-inferiority or equivalence margin

Value

samplesize

References

Chow S, Shao J, Wang H. 2008. Sample Size Calculations in Clinical Research. 2nd Ed. Chapman & Hall/CRC Biostatistics Series.

Yin, G. 2012. Clinical Trial Design: Bayesian and Frequentist Adaptive Methods. John Wiley & Sons.

Examples

##The comparison of proportions, an equivalence trial and the equivalence margin is 0.2
ssc_propcomp(design = 4L, ratio = 1, alpha = 0.05, power = 0.8, p1 = 0.75, p2 = 0.80, delta = 0.2)

Example output

  Treatment Control
1       133     133

SampleSize4ClinicalTrials documentation built on Jan. 13, 2021, 9:58 a.m.