analyse_aft: Analyse Dataset with accelarated failure time models

In SimNPH: Simulate Non-Proportional Hazards

Analyse Dataset with accelarated failure time models

Description

Analyse Dataset with accelarated failure time models

Usage

analyse_aft(level = 0.95, dist = "weibull", alternative = "two.sided")

Arguments

level	confidence level for CI computation
dist	passed to survival::survreg
alternative	alternative hypothesis for the tests "two.sided" or "one.sieded"

Details

alternative can be "two.sided" for a two sided test of equality of the summary statistic or "one.sided" for a one sided test testing H0: treatment has equal or shorter survival than control vs. H1 treatment has longer survival than control.

Value

an analyse function that returns a list with the elements

• p p value of the score test (two.sided) or the Wald test (one.sided)

• alternative the alternative used

• coef coefficient for trt

• lower lower 95% confidence intervall boundary for the coefficient

• upperlower 95% confidence intervall boundary for the coefficient

• CI_level the CI level used

• N_pat number of patients

• N_evt number of events

Examples

condition <- merge(
  assumptions_delayed_effect(),
  design_fixed_followup(),
  by = NULL
) |>
  head(1)
dat <- generate_delayed_effect(condition)
analyse_aft()(condition, dat)
analyse_aft(dist="lognormal")(condition, dat)

SimNPH documentation built on April 12, 2025, 9:13 a.m.