taNegbin.LimitRestMLE: taNegbin.LimitRestMLE

Description Usage Arguments Value

Description

Limit of restricted maximum-likelihood estimator in case of negative binomial distributed endpoints

Usage

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taNegbin.LimitRestMLE(rateExp1, rateRef1, ratePla1, shape1, Delta,
  allocation = c(1/3, 1/3, 1/3))

Arguments

rateExp1

A numeric value specifying the rate of the experimental treatment group in the alternative hypothesis

rateRef1

A numeric value specifying the rate of the reference treatment group in the alternative hypothesis

ratePla1

A numeric value specifying the rate of the placebo treatment group in the alternative hypothesis

shape1

A numeric value specifying the shape parameter

Delta

A numeric value specifying the non-inferiority/superiority margin

allocation

A (non-empty) vector specifying the sample size allocation (wExp, wRef, wPla)

Value

A list containing the following components:

rateExp0, rateRef0, rateRef0

The limit of the maximum-likelihood estimator for the rates when estimed restricted to the boundary of the null hypothesis

shape0

The limit of the maximum-likelihood estimator for the shape parameter when estimated restricted to the boundary of the null hypothesis

sigma2.rest

The limit of the maximum-likelihood variance estimator for the Wald-type test when restricted to the boundary of the null hypothesis


ThreeArmedTrials documentation built on May 2, 2019, 3:28 p.m.