StaggeredRecruiter: Generate enrollment time from piecewise constant uniform...

In TrialSimulator: Clinical Trial Simulator

Generate enrollment time from piecewise constant uniform distribution

Description

Accrual rate can be 10 patients/months for the first 2 months, 20 patients/ months for the second 2 months, and eventually 30 patients/months until the end of trial.

Usage

StaggeredRecruiter(n, accrual_rate)

Arguments

n	number of random numbers
accrual_rate	a data frame of columns end_time: End time for a constant rate in a time window. The start time of the first time window is 0. piecewise_rate: A constant rate in a time window. So the number of patients being recruited in that window is window length x piecewise_rate

Examples

accrual_rate <- data.frame(
  end_time = c(12, 13:17, Inf),
  piecewise_rate = c(15, 15 + 6 * (1:5), 45)
)

accrual_rate <- data.frame(
  end_time = c(3, 4, 5, 8, Inf),
  piecewise_rate = c(1, 2, 2, 3, 4)
)

StaggeredRecruiter(30, accrual_rate)

TrialSimulator documentation built on Sept. 9, 2025, 5:26 p.m.