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A system to simulate clinical trials with time to event endpoints. Event simulation is based on Cox models allowing for covariates in addition to the treatment or group factor. Specific drop-out rates (separate from administrative censoring) can be controlled in the simulation. Other features include stratified randomization, non-proportional hazards, different accrual patterns, and event projection (timing to reach the target event) based on interim data.
Package details |
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Author | Bo Zhang [cre, aut], Yi Zhong [aut, ctb], Ginny Peng [aut, ctb], Bin Yao [aut, ctb] |
Maintainer | Bo Zhang <bzhang@pumabiotechnology.com> |
License | GPL (>= 2) |
Version | 0.2 |
Package repository | View on CRAN |
Installation |
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