R/UncertainInterval.R

In UncertainInterval: Uncertain Interval Methods for Three-Way Cut-Point Determination in Test Results

#' @title Set of functions for the determination of an Uncertain Interval of
#'   test scores
#'
#' @description A collection of functions to determine a range of test scores
#'   that are inconclusive and do not allow a diagnosis (other than Uncertain)
#'   and to access its qualities.
#'
#' @seealso \code{\link{ui.nonpar}},  \code{\link{plotMD}},
#'   \code{\link{get.intersection}},  \code{\link{quality.threshold}},
#'   \code{\link{quality.threshold.uncertain}}
#' @name UncertainInterval
#' @details Uncertain test scores are scores that have about the same density in
#'   the two distributions of patients with and without the targeted condition.
#'   This range is typically found around the optimal cut-point, that is the
#'   point of intersection or Youden index (Schisterman et al., 2005).
#'
#'   From version 0.7 onward, tests with lower values that indicate the presence
#'   of the targeted condition can be analyzed without having to take negative
#'   values for the test. Version 0.7 also corrects four bugs (see
#'   \href{https://github.com/HansLandsheer/UncertainInterval/issues}{Github
#'   UncertainInterval Issues}). Lastly, version 0.7 introduces four ShinyApps
#'   that allow for hands-on simulation of the methods ui.binormal, TG.ROC,
#'   grey-zone and ROC. These examples are documented within the ShinyApp's and
#'   show how they work with a large variety of different tests of varying
#'   qualities.
#'
#'   \describe{ \item{Criteria}{Most functions in this package use a specified
#'   low value for the sensitivity and specificity of the test scores within the
#'   uncertain interval to find this uncertain interval (default UI.Se = UI.Sp =
#'   .55). The most recent added function \code{\link{RPV}} for ordinal test
#'   scores uses the odds of the target condition of near 1 to identify the
#'   uncertain interval (default < 2). This library also contains two
#'   alternative definitions. 1. Coste et al. (2003) defined a grey zone in
#'   between positive and negative conclusions (see \code{\link{greyzone}}),
#'   minimum desired values for respectively the positive and negative post-test
#'   probability, with defaults .95 and .05. 2. Greiner (1995) defined a middle
#'   inconclusive zone of intermediate values (see \code{\link{TG.ROC}}), with
#'   desired minimum values for dichotomous Se and Sp, with default values of
#'   .9. See Index for all available functions and plot possibilities.}
#'   \item{Glossary}{ In general, the prefix MCI is used when a statistic is
#'   calculated for the test scores that are used for a positive or negative
#'   classification. The prefix UI is used when the statistic is applied to the
#'   test scores in the uncertain interval. \itemize{ \item{Se and Sp}{Se and Sp
#'   are statistics that are developed for a single dichotomous cut-point.}
#'   \item{MCI.Se and MCI.Sp}{ Sensitivity and specificity calculated for the
#'   More Certain Intervals (MCIs) outside the Uncertain Interval (UI), that is,
#'   omitting the test scores in the UI. The meaning of Se and Sp changes from
#'   sensitivity and specificity of the test (or all test scores) to sensitivy
#'   and specificity of the test scores used for classification.} \item{UI.Se
#'   and UI.Sp}{Sensitivity and specificity for the test scores inside the
#'   uncertain interval. Please note that the uncertain interval always falls
#'   around the point of intersection (optimal threshold or Youden threshold)
#'   and that for the calculation of UI.Se and UI.Sp the point of intersection
#'   is used as threshold within the uncertain interval.} \item{NPV and
#'   PPV}{Predictive values for respectively the negative and the positive
#'   class. Can be used with both dichotomous and trichotomous sections of the
#'   test scores. The prefix MCI is sometimes used, but is superfluous.}
#'   \item{PV.class}{Predictive value for class when the meaning of class is
#'   selfexplanatory.} \item{NPV.class and PPV.class} {Negative and Positive
#'   Predictive value when the scores in class are used for a negative,
#'   respectively positive classification. When predictive values are calculated
#'   for the same class, NPV.class = 1 - PPV.class. } \item{NPV.ui and PPV.ui}
#'   {Negative and Positive Predictive value when all test scores in the
#'   uncertain interval would be used for a negative, respectively positive
#'   classification. These values can be expected to be close to .5. When
#'   predictive values are calculated for the same class, NPV.ui = 1 - PPV.ui.}
#'   \item{UI.NPV and UI.PPV}{Negative and Positive Predictive value when test
#'   scores in the uncertain interval respectively above and below the point of
#'   intersection would be used for a negative, respectively positive
#'   classification. These values can be expected to be close to .5, but
#'   slightly higher than NPV.ui and PPV.ui} \item{SNPV, SPPV, SPV.class,
#'   SNPV.class, SPPV.class, SNPV.ui, SPPV.ui, UI.SNPV and UI.SPPV}{The
#'   standardized versions of the predictive values mentioned above.} } } }
#' @references Landsheer, J. A. (2016). Interval of Uncertainty: An Alternative
#'   Approach for the Determination of Decision Thresholds, with an Illustrative
#'   Application for the Prediction of Prostate Cancer. PloS One, 11(11),
#'   e0166007.
#'
#'   Landsheer, J. A. (2018). The Clinical Relevance of Methods for Handling
#'   Inconclusive Medical Test Results: Quantification of Uncertainty in Medical
#'   Decision-Making and Screening. Diagnostics, 8(2), 32.
#'   https://doi.org/10.3390/diagnostics8020032
#'
#'   Schisterman, E. F., Perkins, N. J., Liu, A., & Bondell, H. (2005). Optimal
#'   cut-point and its corresponding Youden Index to discriminate individuals
#'   using pooled blood samples. Epidemiology, 73-81.
#'
#'   Greiner, M. (1995). Two-graph receiver operating characteristic (TG-ROC): A
#'   Microsoft-EXCEL template for the selection of cut-off values in diagnostic
#'   tests. Journal of Immunological Methods, 185(1), 145-146.
#'
#'   Coste, J., & Pouchot, J. (2003). A grey zone for quantitative diagnostic
#'   and screening tests. International Journal of Epidemiology, 32(2), 304-313.


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