compute_framingham: Compute Framingham Heart Study Cardiovascular Disease 10-Year...

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Compute Framingham Heart Study Cardiovascular Disease 10-Year Risk Score

Description

Computes Framingham Heart Study Cardiovascular Disease 10-Year Risk Score (FCVD101) based on systolic blood pressure, total serum cholesterol (mg/dL), HDL serum cholesterol (mg/dL), sex, smoking status, diabetic status, and treated for hypertension flag.

Usage

compute_framingham(sysbp, chol, cholhdl, age, sex, smokefl, diabetfl, trthypfl)

Arguments

sysbp	Systolic blood pressure A numeric vector is expected.
chol	Total serum cholesterol (mg/dL) A numeric vector is expected.
cholhdl	HDL serum cholesterol (mg/dL) A numeric vector is expected.
age	Age (years) A numeric vector is expected.
sex	Gender A character vector is expected. Expected Values: 'M' 'F'
smokefl	Smoking Status A character vector is expected. Expected Values: 'Y' 'N'
diabetfl	Diabetic Status A character vector is expected. Expected Values: 'Y' 'N'
trthypfl	Treated for hypertension status A character vector is expected. Expected Values: 'Y' 'N'

Details

The predicted probability of having cardiovascular disease (CVD) within 10-years according to Framingham formula. See AHA Journal article General Cardiovascular Risk Profile for Use in Primary Care for reference.

For Women:

Factor	Amount
Age	2.32888
Total Chol	1.20904
HDL Chol	-0.70833
Sys BP	2.76157
Sys BP + Hypertension Meds	2.82263
Smoker	0.52873
Non-Smoker	0
Diabetic	0.69154
Not Diabetic	0
Average Risk	26.1931
Risk Period	0.95012

For Men:

Factor	Amount
Age	3.06117
Total Chol	1.12370
HDL Chol	-0.93263
Sys BP	1.93303
Sys BP + Hypertension Meds	2.99881
Smoker	.65451
Non-Smoker	0
Diabetic	0.57367
Not Diabetic	0
Average Risk	23.9802
Risk Period	0.88936

The equation for calculating risk:

RiskFactors = (log(Age) * AgeFactor) + (log(TotalChol) * TotalCholFactor) + (log(CholHDL) * CholHDLFactor) \\ + (log(SysBP) * SysBPFactor) + Smoker + Diabetes Present - AvgRisk

Risk = 100 * (1 - RiskPeriodFactor ^ exp(RiskFactors))

Value

A numeric vector of Framingham values

See Also

derive_param_framingham()

BDS-Findings Functions that returns a vector: compute_bmi(), compute_bsa(), compute_egfr(), compute_map(), compute_qtc(), compute_qual_imputation_dec(), compute_qual_imputation(), compute_rr(), compute_scale()

Examples

compute_framingham(
  sysbp = 133, chol = 216.16, cholhdl = 54.91, age = 53,
  sex = "M", smokefl = "N", diabetfl = "N", trthypfl = "N"
)

compute_framingham(
  sysbp = 161, chol = 186.39, cholhdl = 64.19, age = 52,
  sex = "F", smokefl = "Y", diabetfl = "N", trthypfl = "Y"
)

admiral documentation built on Oct. 19, 2023, 1:08 a.m.