Provides the functions for planning and conducting a clinical trial with adaptive sample size determination. Maximal statistical efficiency will be exploited even when dramatic or multiple adaptations are made. Such a trial consists of adaptive determination of sample size at an interim analysis and implementation of frequentist statistical test at the interim and final analysis with a prefixed significance level. The required assumptions for the stage-wise test statistics are independent and stationary increments and normality. Predetermination of adaptation rule is not required.
Package details |
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Author | Kosuke Kashiwabara [aut, cre] |
Maintainer | Kosuke Kashiwabara <kashiwabara-tky@umin.ac.jp> |
License | GPL (>= 2) |
Version | 0.1.2 |
URL | https://github.com/ca4wa/R-adpss |
Package repository | View on CRAN |
Installation |
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