adpss: Design and Analysis of Locally or Globally Efficient Adaptive Designs

Provides the functions for planning and conducting a clinical trial with adaptive sample size determination. Maximal statistical efficiency will be exploited even when dramatic or multiple adaptations are made. Such a trial consists of adaptive determination of sample size at an interim analysis and implementation of frequentist statistical test at the interim and final analysis with a prefixed significance level. The required assumptions for the stage-wise test statistics are independent and stationary increments and normality. Predetermination of adaptation rule is not required.

Package details

AuthorKosuke Kashiwabara [aut, cre]
MaintainerKosuke Kashiwabara <>
LicenseGPL (>= 2)
Package repositoryView on CRAN
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adpss documentation built on Dec. 9, 2022, 5:09 p.m.