Provides the functions for planning and conducting a clinical trial with adaptive sample size determination. Maximal statistical efficiency will be exploited even when dramatic or multiple adaptations are made. Such a trial consists of adaptive determination of sample size at an interim analysis and implementation of frequentist statistical test at the interim and final analysis with a prefixed significance level. The required assumptions for the stage-wise test statistics are independent and stationary increments and normality. Predetermination of adaptation rule is not required.
|Author||Kosuke Kashiwabara [aut, cre]|
|Maintainer||Kosuke Kashiwabara <[email protected]>|
|License||GPL (>= 2)|
|Package repository||View on CRAN|
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