This building block declares a mixed linear and nonlinear elimination component for a pharmacokinetic model.
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Parameter model for the linear clearance
Parameter model for the non-linear clearance
Parameter model for KM (the half-maximal concentration)
Parameter model for Vmax (the maximal elimination rate)
PK components can be added to a pk_model and exist in three different types: absorption, distribution, and elimination. The absorption component is optional, distribution and elimination are not and need to be added for the PK model to be valid.
A PK model can only have one component of each type and adding a component with an already existing type will replace the previous definition. For example, the distribution component will be a two compartment model in the following snippet:
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All PK component functions allow the specification of the parameter
model via their arguments. Arguments that refer to a parameter start
with the prefix
prm_. The default parameter model can be deduced from
the default arguments in the usage section of the help entry. The
parameter name, specified via the
name= argument of the parameter
model building block allows the renaming of the model parameters.
For example, the parameter
prm_vc= refers to the central volume of
distribution parameter in the one compartment distribution PK component
and the default parameter model is a log-normal distribution. The
following code block specifies a normal distribution parameter model and
names the parameter
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A building block of type 'pk_component'
pk_model() for the creation of PK models
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