setup_mmlglobal: Setup mmlglobal Design Object

In basksim: Simulation-Based Calculation of Basket Trial Operating Characteristics

Setup mmlglobal Design Object

Description

Creates an object of class mmlglobal.

Usage

setup_mmlglobal(k, p0, shape1 = 1, shape2 = 1)

Arguments

k	The number of baskets.
p0	A common probability under the null hypothesis.
shape1	First common shape parameter of the beta prior.
shape2	Second common shape parameter of the beta prior.

Details

The class mmlglobal implements an empirical Bayes method by Gravestock & Held (2019) which was proposed for borrowing strength from multiple external studies.

Value

An S3 object of class mmlglobal

References

Gravestock, I., & Held, L. (2019). Power priors based on multiple historical studies for binary outcomes. Biometrical Journal, 61(5), 1201-1218.

Baumann, L., Sauer, L., & Kieser, M. (2024). A basket trial design based on power priors. arXiv:2309.06988.

Examples

design_mmlglobal <- setup_mmlglobal(k = 3, p0 = 0.2)

basksim documentation built on June 24, 2024, 5:13 p.m.