# Binary sequential tests

### Description

Design and analyze binary sequential tests

### Details

Package: | binseqtest |

Type: | Package |

Version: | 1.0.2 |

Date: | 2016-10-12 |

License: | GPL (>=2) |

LazyLoad: | yes |

The package creates designs for testing a series of binary responses sequentially. It allows checking after every response, or grouped sequential tests. Gives exact confidence intervals and p-values. Has an option for non-binding futility boundaries.

There are functions for creating the binary sequential boundaries or binary grouped sequential boundaries (see `designOBF`

),
creating tables of statistics (estimates, confidence intervals, and p-values) at
specific stopping points in the boundary (see `link{stopTable}`

), modifying the boundaries (see `modify`

),
and plotting the boundaries (`plot-methods`

).

For details see Kirk and Fay (2014).

### Author(s)

Jenn Kirk, Michael P. Fay

### References

Kirk, JL, and Fay, MP (2014). An Introduction to Practical Sequential Inferences via Single Arm Binary Response Studies Using the binseqtest R Package. (to appear in American Statistician).

### Examples

1 2 3 4 5 6 7 8 9 | ```
# create an O'Brien-Fleming-type design, with 2.5 percent error on each side with max N of 50
B<-designOBF(50)
# plot it
plot(B)
# create a table for N (total samples) values between 20 and 25
stopTable(B,Nrange=c(20,25))
# modify the boundary if you missed looks at N=30 through 35
Bmod<-modify(B,missN=30:35)
plot(Bmod)
``` |