caffConcTimeMulti: Create a dataset of the concentration-time curve of multiple...

In caffsim: Simulation of Plasma Caffeine Concentrations by Using Population Pharmacokinetic Model

Description

caffConcTimeMulti will create a dataset of the concentration-time curve of multiple oral administrations of caffeine

Usage

caffConcTimeMulti(Weight, Dose, N = 20, Tau = 8, Repeat = 4)

Arguments

Weight	Body weight (kg)
Dose	Dose of single caffeine (mg)
N	The number of simulated subjects
Tau	The interval of multiple dosing (hour)
Repeat	The number of dosing

Value

The dataset of concentration and time of simulated subjects of multiple dosing

See Also

https://asancpt.github.io/caffsim

Examples

caffConcTimeMulti(Weight = 20, Dose = 200, N = 20, Tau = 8, Repeat = 4)
caffConcTimeMulti(20, 200)

Example output

# A tibble: 19,220 x 3
# Groups:   Subject [20]
   Subject  Time  Conc
     <dbl> <dbl> <dbl>
 1       1   0    0   
 2       1   0.1  9.02
 3       1   0.2 12.8 
 4       1   0.3 14.3 
 5       1   0.4 14.9 
 6       1   0.5 15.1 
 7       1   0.6 15.1 
 8       1   0.7 15.0 
 9       1   0.8 14.9 
10       1   0.9 14.8 
# ... with 19,210 more rows
# A tibble: 19,220 x 3
# Groups:   Subject [20]
   Subject  Time  Conc
     <dbl> <dbl> <dbl>
 1       1   0    0   
 2       1   0.1  7.00
 3       1   0.2 11.2 
 4       1   0.3 13.6 
 5       1   0.4 15.0 
 6       1   0.5 15.8 
 7       1   0.6 16.1 
 8       1   0.7 16.2 
 9       1   0.8 16.2 
10       1   0.9 16.1 
# ... with 19,210 more rows

caffsim documentation built on May 2, 2019, 3:45 p.m.