caffDescstat: Calculate descriptive statistics of simulated PK parameters

In caffsim: Simulation of Plasma Caffeine Concentrations by Using Population Pharmacokinetic Model

Description

caffDescstat will calculate descriptive statistics of simulated PK parameters

Usage

caffDescstat(caffPkparamData)

Arguments

caffPkparamData

data frame generated by caffPkparam function

Value

The descriptive statistics of pharmacokinetic parameters

See Also

https://asancpt.github.io/caffsim

Examples

caffDescstat(caffPkparam(20,500))
caffDescstat(caffPkparamMulti(20,500))
caffDescExample <- cbind(caffDescstat(caffPkparam(20,500)), 
                         caffDescstat(caffPkparam(50,500))[,2])
colnames(caffDescExample)[2:3] <- c('20 kg', '50 kg')      
caffDescExample

Example output

# A tibble: 8 x 2
  `PK parameters` `value: mean (sd) [min-max]`   
  <chr>           <chr>                          
1 AUC             287.86 (110.17) [119.07-598.97]
2 CL              1.99 (0.81) [0.83-4.20]        
3 Cmax            32.89 (7.15) [22.83-47.92]     
4 Half_life       5.41 (1.61) [2.96-9.33]        
5 Ka              7.31 (5.91) [0.80-24.28]       
6 Ke              0.14 (0.04) [0.07-0.23]        
7 Tmax            0.86 (0.65) [0.21-2.72]        
8 V               14.13 (2.61) [9.44-18.49]      
# A tibble: 8 x 2
  `PK parameters` `value: mean (sd) [min-max]`   
  <chr>           <chr>                          
1 AI              1.45 (0.19) [1.17-1.75]        
2 AUCS            251.37 (87.89) [103.39-422.75] 
3 Aavss           421.42 (110.03) [259.92-588.00]
4 Cavss           31.42 (10.99) [12.92-52.84]    
5 CmaxS           32.64 (7.33) [21.52-45.15]     
6 Cmaxss          53.55 (13.74) [28.19-79.45]    
7 Cminss          16.74 (8.31) [4.51-32.97]      
8 TmaxS           0.93 (0.82) [0.04-3.43]        
  PK parameters                           20 kg                         50 kg
1           AUC 266.80 (106.93) [146.93-541.05] 103.76 (40.78) [58.78-208.73]
2            CL         2.14 (0.76) [0.92-3.40]       5.41 (1.73) [2.40-8.51]
3          Cmax     33.79 (11.15) [18.90-61.94]     12.18 (3.30) [7.92-18.66]
4     Half_life         4.80 (1.23) [3.03-6.65]       5.15 (1.24) [3.51-7.89]
5            Ka        7.03 (8.42) [0.79-39.33]      5.20 (4.12) [1.26-16.06]
6            Ke         0.15 (0.04) [0.10-0.23]       0.14 (0.03) [0.09-0.20]
7          Tmax         0.92 (0.62) [0.14-2.55]       0.96 (0.45) [0.28-1.88]
8             V       13.90 (3.24) [7.89-19.62]    38.19 (9.31) [24.17-54.97]

caffsim documentation built on May 2, 2019, 3:45 p.m.