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#' Non-parametric cluster bootstrap to make inference on the concordance correlation coefficient
#' @keywords internal
#' @param dataset an object of class \code{data.frame}
#' @param ry Character string. Name of the outcome in the data set.
#' @param rind Character string. Name of the subject variable in the data set.
#' @param rmet Character string. Name of the method variable in the data set.
#' @param rtime Character string. Name of the time variable in the data set.
#' @param vecD Vector of weights. The length of the vector must be the same as the number of repeated measures.
#' @param covar Character vector. Name of covariates to include in the linear mixed model as fixed effects.
#' @param int Binary indicating if the subject-method interaction has to be included in the model when analyzing the non-longitudinal setting (defaults to FALSE).
#' @param rho Within subject correlation structure. A value of 0 (default option) stands for compound symmetry and 1 is used for autorregressive of order 1 structure.
#' @param cl Confidence level.
#' @param control.lme A list of control values for the estimation algorithm used in \code{lme} function. For further details see \code{lme} help.
#' @param nboot Number of bootstrap resamples.
#' @param parallel Whether the code is parallellized. The parallellization method is \code{multisession}.
#' @param future_seed Logical/Integer. The seed to be used for parallellization. Further details in \code{furrr_options}.
#' @return Vector of CCC bootstrap estimates.
np_boot_ci <- function(dataset,ry, rind, rtime = NULL, rmet = NULL,
vecD = NULL, covar = NULL, rho = 0, int = FALSE,
cl = 0.95, control.lme = list(),
nboot = 500,parallel=TRUE,
future_seed=123){
# Resample matrix
dades<-dataset
ns <- length(unique(as.character(unlist(dades[,rind]))))
dots <- as.name(rind)
grouped <- dplyr::group_by(dades, !!dots)
g_rows <- dplyr::group_rows(grouped)
id <- seq_along(g_rows)
Bmat <- matrix(sample(rep(id,nboot)),nrow=length(id),byrow=FALSE)
if(anyNA(Bmat)){
warning("NA values in resample matrix.")
}
# Compute resamples
if(!parallel){
with_progress({
p <- progressr::progressor(steps = nboot)
ccc_resamples<-purrr::map(as.integer(1:nboot), function(i){
p()
Sys.sleep(.2)
resamp_ccc(i,Bmat,dades,g_rows,ns,ry,rtime,
rmet,vecD, covar, rho, int, cl,control.lme)
}
)
ccc_resamples<-unlist(ccc_resamples)
},enable=TRUE)
}
if(parallel){
with_progress({
p <- progressr::progressor(steps = nboot)
ccc_resamples<-furrr::future_map(as.integer(1:nboot), ~ {
p()
Sys.sleep(.2)
resamp_ccc(.x,Bmat,dades,g_rows,ns,ry,rtime,
rmet,vecD, covar, rho, int, cl,control.lme)
}, .options = furrr::furrr_options(seed = future_seed),
p = p
)
ccc_resamples<-unlist(ccc_resamples)
},enable=TRUE)
}
return(ccc_resamples)
}
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