methylation: DNA Methylation, childhood trauma, and stress response

In cmfilter: Coordinate-Wise Mediation Filter

Description

A dataset containing variables on childhood trauma, stress response, and 1000 preprocessed epigenetic methylation values. This dataset was synthesised using the synthpop package to remove any identifying information.

Usage

methylation

Format

A data frame with 85 rows and 1002 variables: a composite score on a childhood trauma questionnaire (x), a measure of increase in area under the curve of cortisol after stress task (y), and beta values of methylation at 1000 different locations in the genome.

References

Houtepen, L. C., Vinkers, C. H., Carrillo-Roa, T., Hiemstra, M., Van Lier, P. A., Meeus, W., ... & Schalkwyk, L. C. (2016). Genome-wide DNA methylation levels and altered cortisol stress reactivity following childhood trauma in humans. Nature communications, 7, 10967.

van Kesteren, E. J., & Oberski, D. L. (2018). Exploratory Mediation Analysis with Many Potential Mediators. arXiv preprint arXiv:1810.06334.

cmfilter documentation built on April 11, 2019, 5:07 p.m.